Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring

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dc.contributor.author Silva, Sergio Gomes da [UNIFESP]
dc.contributor.author Almeida, Alexandre Aparecido de [UNIFESP]
dc.contributor.author Fernandes, Jansen [UNIFESP]
dc.contributor.author Lopim, Glauber Menezes [UNIFESP]
dc.contributor.author Cabral, Francisco Romero
dc.contributor.author Scerni, Débora Amado [UNIFESP]
dc.contributor.author Oliveira-Pinto, Ana Virginia de
dc.contributor.author Lent, Robert
dc.contributor.author Arida, Ricardo Mario [UNIFESP]
dc.date.accessioned 2017-01-03T10:25:02Z
dc.date.available 2017-01-03T10:25:02Z
dc.date.issued 2016-01-15
dc.identifier http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147200 pt
dc.identifier.citation SILVA, Sergio Gomes da, et al. Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring. PLoS ONE 11(1): e0147200, 2016.
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/41266
dc.description Clinical evidence has shown that physical exercise during pregnancy may alter brain devel- opment and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects are not well understood. The present study examined levels of brain-derived neurotrophic factor (BDNF) and absolute cell num- bers in the hippocampal formation and cerebral cortex of rat pups born from mothers exer- cised during pregnancy. Additionally, we evaluated the cognitive abilities of adult offspring in different behavioral paradigms (exploratory activity and habituation in open field tests, spatial memory in a water maze test, and aversive memory in a step-down inhibitory avoid- ance task). Results showed that maternal exercise during pregnancy increased BDNF lev- els and absolute numbers of neuronal and non-neuronal cells in the hippocampal formation of offspring. No differences in BDNF levels or cell numbers were detected in the cerebral cortex. It was also observed that offspring from exercised mothers exhibited better cognitive performance in nonassociative (habituation) and associative (spatial learning) mnemonic tasks than did offspring from sedentary mothers. Our findings indicate that maternal exer- cise during pregnancy enhances offspring cognitive function (habituation behavior and spa- tial learning) and increases BDNF levels and cell numbers in the hippocampal formation of offspring. pt
dc.description.abstract Clinical evidence has shown that physical exercise during pregnancy may alter brain devel- opment and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects are not well understood. The present study examined levels of brain-derived neurotrophic factor (BDNF) and absolute cell num- bers in the hippocampal formation and cerebral cortex of rat pups born from mothers exer- cised during pregnancy. Additionally, we evaluated the cognitive abilities of adult offspring in different behavioral paradigms (exploratory activity and habituation in open field tests, spatial memory in a water maze test, and aversive memory in a step-down inhibitory avoid- ance task). Results showed that maternal exercise during pregnancy increased BDNF lev- els and absolute numbers of neuronal and non-neuronal cells in the hippocampal formation of offspring. No differences in BDNF levels or cell numbers were detected in the cerebral cortex. It was also observed that offspring from exercised mothers exhibited better cognitive performance in nonassociative (habituation) and associative (spatial learning) mnemonic tasks than did offspring from sedentary mothers. Our findings indicate that maternal exer- cise during pregnancy enhances offspring cognitive function (habituation behavior and spa- tial learning) and increases BDNF levels and cell numbers in the hippocampal formation of offspring. pt
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.language.iso eng pt
dc.publisher Plos One pt
dc.rights Acesso aberto pt
dc.subject brain-derived neurotrophic factor pt
dc.title Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring pt
dc.type Artigo pt
dc.description.sponsorshipID FAPESP: 09/06953-4
dc.description.sponsorshipID FAPESP: 10/11353-3
dc.identifier.doi 10.1371/journal.pone.0147200 pt



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