Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil

Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil

Autor Divino-Goes, K.g. Autor UNIFESP Google Scholar
De Moraes-Pinto, Maria Isabel Autor UNIFESP Google Scholar
Dinelli, Maria Isabel Saraiva Autor UNIFESP Google Scholar
Casagrande, Silvana Tadeu Google Scholar
Bonetti, Tatiana Carvalho de Souza Autor UNIFESP Google Scholar
Andrade, P.r. Google Scholar
Weckx, Lily Yin Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Instituto Adolfo Lutz
Centro Assistencial Cruz de Malta
Resumo The introduction of routine vaccination against tetanus and diphtheria in Brazil has decreased the incidence and changed the epidemiology of both diseases. We then investigated the prevalence of Corynebacterium diphtheriae carrier status and diphtheria and tetanus immunity in São Paulo, Brazil. From November 2001 to March 2003, 374 individuals were tested for the presence of C. diphtheriae in the naso-oropharynx and of serum diphtheria and tetanus antibodies. Participants were all healthy individuals without acute or chronic pathologies and they were stratified by age as follows: 0-12 months and 1-4, 5-9, 10-14, 15-24, 25-39, 40-59, and ³60 years. Antibodies were assessed using a double-antigen ELISA. C. diphtheriae species were identified by biochemical analysis and toxigenicity was assessed by the Elek test. For diphtheria, full protection (antibodies ³0.1 IU/mL) was present in 84% of the individuals, 15% had basic protection (antibodies ³0.01 and <0.1 IU/mL) and 1% were susceptible (antibodies <0.01 IU/mL). Full tetanus protection (antibodies ³0.1 IU/mL) was present in 79% of the participants, 18% had basic protection (antibodies ³0.01 and <0.1 IU/mL) and 3% were susceptible (antibodies <0.01 IU/mL). The geometric mean of diphtheria and tetanus antibodies reached the highest values at 5-9 years and decreased until the 40-59-year age range, increasing again in individuals over 60 years. Three participants (0.8%) were carriers of C. diphtheriae, all non-toxigenic strains. The present results demonstrate the clear need of periodic booster for tetanus and diphtheria vaccine in adolescents and adults after primary immunization in childhood.
Palavra-chave Diphtheria
Tetanus
Corynebacterium diphtheriae
Vaccine
Immunization
Antibody
Idioma Inglês
Data de publicação 2007-12-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 12, p. 1681-1687, 2007.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1681-1687
Fonte http://dx.doi.org/10.1590/S0100-879X2006005000184
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000252843900012
SciELO S0100-879X2007001200012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4018

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