Osteosarcoma in patients younger than 12 years old without metastases have similar prognosis as adolescent and young adults

Osteosarcoma in patients younger than 12 years old without metastases have similar prognosis as adolescent and young adults

Author Prates Eleuterio, Sabrina Jeane Autor UNIFESP Google Scholar
Senerchia, Andreza Almeida Autor UNIFESP Google Scholar
Almeida, Maria Teresa Google Scholar
Da Costa, Cecilia Maria Google Scholar
Lustosa, Daniel Google Scholar
Calheiros, Luiz Mario Google Scholar
Silva Barreto, Jose Henrique Google Scholar
Brunetto, Algemir Lunardi Google Scholar
Pacheco Donato Macedo, Carla Renata Autor UNIFESP Google Scholar
Petrilli, Antonio Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Hosp Canc AC Camargo
Hosp Canc Ceara
Soc Pernambucana Combate Ao Canc
Soc Oncol Bahia
Hosp Clin Porto Alegre
Abstract BackgroundChildhood cancer is relatively rare and tends to present specific age distribution, as a prognostic factor for some of these diseases. Information on how young age affects prognosis, response to chemotherapy, and local control options in children versus AYA with osteosarcoma (OST) is minimal.MethodsIn order to identify the main differences in clinicalpathologic features, surgical approaches and survival rates of primary high grade OST of the extremity between children (n=156; <12 years old) and AYA (n=397; 12-30 years old), the institutional database with 553 patients treated by BOTG studies over 15 years were reviewed.ResultsThere were no differences in metastasess at diagnosis, tumor size, and grade of necrosis between the two age groups. the rate of amputation was 30% higher in the children group (P=0.018). the rate of limb salvage surgery using reconstruction with allograft or autograft was 70% higher in the children group (P=0.018) while endoprosthesis rate was 40% higher in the AYA group (P=0.018). the log rank test revealed that survival is similar between the two age groups for non-metastatic patients (P=0.424 for OS and P=0.393 for EFS). Metastatic patients of both ages group had higher risk of dying compared to non-metastatic (HR 3.283 95% CI 2.581-4.177; P<0.001). Children with metastases at diagnosis had less OS time (P=0.049) and EFS time (P=0.032) than adolescents.ConclusionNon-metastatic OST in preadolescent patients does not appear to be significantly differentfrom those seen in AYA patients, but has local control challenges. Children presenting with metastases should be considered an ultra-high-risk group. Pediatr Blood Cancer 2015;62:1209-1213. (c) 2015 Wiley Periodicals, Inc.
Keywords adolescent
amputation
chemotherapy
childhood bone cancer
children
osteosarcoma
young adult
Language English
Date 2015-07-01
Published in Pediatric Blood & Cancer. Hoboken: Wiley-Blackwell, v. 62, n. 7, p. 1209-1213, 2015.
ISSN 1545-5009 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1209-1213
Origin http://dx.doi.org/10.1002/pbc.25459
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000354541600020
URI http://repositorio.unifesp.br/handle/11600/39145

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