Impact of chronic obstructive pulmonary disease on exercise ventilatory efficiency in heart failure

Impact of chronic obstructive pulmonary disease on exercise ventilatory efficiency in heart failure

Autor Apostolo, Anna Google Scholar
Laveneziana, PierAntonio Google Scholar
Palange, Paolo Google Scholar
Agalbato, Cecilia Google Scholar
Molle, Roberta Google Scholar
Popovic, Dejana Google Scholar
Bussotti, Maurizio Google Scholar
Internullo, Mattia Google Scholar
Sciomer, Susanna Google Scholar
Bonini, Matteo Google Scholar
Alencar, Maria Clara Autor UNIFESP Google Scholar
Godinas, Laurent Google Scholar
Arbex, Flavio Autor UNIFESP Google Scholar
Garcia, Gilles Google Scholar
Alberto Neder, J. Autor UNIFESP Google Scholar
Agostoni, Piergiuseppe Google Scholar
Instituição IRCCS
Hopital Univ Bicetre
Univ Paris 06
INSERM
Grp Hosp Pitie Salpetriere Charles Foix
Univ Roma La Sapienza
Univ Belgrade
Fdn Salvatore Maugeri
La Sapienza
Universidade Federal de São Paulo (UNIFESP)
Univ Paris 11
Queens Univ
Univ Milan
Resumo Background: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) coexistence increases morbidity and mortality. the intercept of ventilation ((V) over dotEint) on the (V) over dotE vs. carbon dioxide production ((V) over dot CO2) relationship during exercise has been found to vary in proportion with dead space (VD) in HF. Considering that increased VD is the key pathophysiological abnormality in COPD but a secondary finding in HF we hypothesized that a high (V) over dotEint would be useful in suggesting COPD as HF co-morbidity. Our aim was to assess whether an elevated (V) over dotEint suggests the presence of COPD in HF.Methods: in a multicenter retrospective study, the (V) over dotE-(V) over dotCO(2) relationship was analyzed both as slope and intercept in HF (n = 108), HF-COPD (n = 106) and COPD (n = 95). Patients with pulmonary arterial hypertension (PAH) (n= 85) and healthy subjects (HF) (n= 56) served as positive and negative controls relative to (V) over dotE-(V) over dotCO(2) abnormalities, respectively.Results: Slope and (V) over dotEint varied in opposite directions in all groups (p < 0.05) being (V) over dotE-(V) over dotCO(2) slope highest and lowest in PAH and healthy subjects, respectively. No slope differences were observed among HF, HF-COPD and COPD (32 +/- 7, 31 +/- 7, and 31 +/- 6, respectively). (V)over dotEint was higher in HF-COPD and COPD compared to HF, PAH and controls (4.8 +/- 2.4 L/min, 5.9 +/- 3.0 L/min, 3.0 +/- 2.6 L/min, 2.3 +/- 3.3 L/min and 3.9 +/- 2.5 L/min, respectively; p < 0.01). A (V) over dotEint >= 4.07 L/min identified patients with high probability of having COPD or HF-COPD (sensitivity of 71.6% and specificity of 72.0%).Conclusion: These data provide novel evidence that a high (V) over dotEint (>= 4.07 L/min) should be valued to suggest coexistent COPD in HF patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Assunto Ventilatory efficiency
Exercise
Dead space
Heart failure
Lung diseases
Idioma Inglês
Financiador Centro Cardiologico Monzino, IRCCS, Milano (Italy)
Data 2015-06-15
Publicado em International Journal of Cardiology. Clare: Elsevier B.V., v. 189, p. 134-140, 2015.
ISSN 0167-5273 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 134-140
Fonte http://dx.doi.org/10.1016/j.ijcard.2015.03.422
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000355108300029
URI http://repositorio.unifesp.br/handle/11600/39142

Mostrar registro completo




Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)