Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

Autor Ono, E. Autor UNIFESP Google Scholar
Santos, A. M. dos Autor UNIFESP Google Scholar
Viana, P. O. Autor UNIFESP Google Scholar
Dinelli, M. I. S. Autor UNIFESP Google Scholar
Sass, N. Autor UNIFESP Google Scholar
De Oliveira, L. Autor UNIFESP Google Scholar
Goulart, A. L. Autor UNIFESP Google Scholar
Moraes-Pinto, M. I. de Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Children born to female kidney recipients are exposed to immunosuppressive drugs during gestation. Little is known about their immune system at birth or in the long term. Twenty-eight children born to female kidney recipients and 40 full-term children born to healthy mothers were evaluated. T, B, NK, NKT, T cells were assessed by flow cytometry and functional evaluation of T and dendritic cells after in vitro activation was performed at birth and at 8 months of age. At birth, infants born to female kidney recipients showed lower numbers of CD4+ T, NKT and intense reduction of B cells (median cells/mm(3), transplant: 153.7 X control: 512.4; p<0.001). There was also a reduced percentage of activated CD8+ T and of CD4+ regulatory T cells. Activated memory and exhausted memory B cells showed higher percentages among children exposed to immunosuppressors when compared to control group. At 8 months, most immune alterations were no longer observed, but four children still had low numbers of some lymphocyte subsets at this age. Children born to female kidney recipients had 4.351 (95% CI: 1.026-15.225; p=0.046) higher risk of hospital admission in the first months of lifesome, with severe clinical manifestationsthan those born to healthy women.
Assunto clinical research
practice
basic (laboratory) research
science
pediatrics
infectious disease
immunosuppression
immune modulation
B cell biology
immune deficiency
immunosuppressant
infection and infectious agents
pregnancy
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 01/11011-6
FAPESP: 08/06232-2
Data 2015-06-01
Publicado em American Journal of Transplantation. Hoboken: Wiley-Blackwell, v. 15, n. 6, p. 1654-1665, 2015.
ISSN 1600-6135 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 1654-1665
Fonte http://dx.doi.org/10.1111/ajt.13143
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000354621200025
URI http://repositorio.unifesp.br/handle/11600/39136

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