Roux-en-Y Gastric Bypass Decreases Pro-inflammatory and Thrombotic Biomarkers in Individuals with Extreme Obesity

Roux-en-Y Gastric Bypass Decreases Pro-inflammatory and Thrombotic Biomarkers in Individuals with Extreme Obesity

Author Netto, Barbara Dal Molin Autor UNIFESP Google Scholar
Bettini, Solange Cravo Google Scholar
Clemente, Ana Paula Grotti Autor UNIFESP Google Scholar
Carvalho Ferreira, Joana Pereira de Autor UNIFESP Google Scholar
Boritza, Katia Google Scholar
Souza, Sandy de Fatima Google Scholar
Von der Heyde, Maria Emilia Google Scholar
Earthman, Carrie P. Google Scholar
Damaso, Ana R. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Paraná (UFPR)
Univ Minnesota Twin Cities
Abstract The low-grade inflammatory state in obesity leads to insulin resistance and endothelial dysfunction, which promote cardiovascular diseases in individuals with obesity. the purpose of this study was to evaluate the early effects of weight loss achieved through bariatric surgery on the inflammatory and prothrombotic states. This study also aimed to identify the role of hyperleptinemia on the prothrombotic state.The sample was composed of 41 extremely obese who underwent Roux-en-Y gastric bypass (RYGB). Anthropometric and clinical data, and biochemical markers of inflammation were collected prior to surgery and 6 months post-RYGB.It was found that plasminogen activator inhibitor-1 (PAI-1) concentrations were higher among extremely obese individuals with hyperleptinemia than in those without hyperleptinemia (p < 0.01).In relation to the baseline, post-surgery body mass index (BMI) was reduced by 12.9 kg/m(2), corresponding to 63.50 % of excess weight loss. Additionally, waist circumference was found to decrease significantly from 126.2 to 101.4 cm. Plasma total cholesterol (p < 0.01), LDL cholesterol (p = 0.02), triglycerides (p < 0.01), and glucose (p = 0.01) were also found to decrease. Pro-inflammatory biomarkers were observed to decrease: PAI-1 by 55.9 +/- 6.0 % (p < 0.01), C-reactive protein (CRP) by 18.8 +/- 3.4 % (p < 0.01), intercellular adhesion molecule-1 (ICAM-1) by 89.9 +/- 5.7 % (p < 0.01), leptin by 27.9 +/- 3.2 % (p < 0.01), and resistin by 69.3 +/- 5.8 % (p < 0.01). Additionally, significant decreases of tumor necrosis factor alpha (TNF-alpha) and leptin/adiponectin ratio were observed. Anti-inflammatory cytokines adiponectin and interleukin-10 (IL-10) were significantly increased (170.7 +/- 82.5 %, p < 0.01; 122.7 +/- 55.1 %, p = 0.02). CRP levels were predictive of ICAM-1 (p = 0.04), and changes in leptin concentrations were associated with decreased PAI-1 levels (p = 0.03).We observed that individuals with obesity that have hyperleptinemia have higher circulating PAI-1 levels, which could indicate increased risk for cardiovascular disease. the biomarkers of inflammation and thrombosis measured in this study decreased after RYGB, suggesting that the surgery may be effective in reducing pro-inflammatory and thrombotic risk in individuals with extreme obesity.
Keywords Roux-en-Y gastric bypass
Obesity
Inflammation
Hyperleptinemia
Cardiovascular
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
UNIFESP-EPM
Grant number FAPESP: 2013/04136-4
CAPES: BEX 2262/14-2
: CAPES 2566/2011
Date 2015-06-01
Published in Obesity Surgery. New York: Springer, v. 25, n. 6, p. 1010-1018, 2015.
ISSN 0960-8923 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1010-1018
Origin http://dx.doi.org/10.1007/s11695-014-1484-7
Access rights Closed access
Type Article
Web of Science ID WOS:000354216500009
URI http://repositorio.unifesp.br/handle/11600/39117

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