Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)

Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)

Author Estevão, Ligia Reis Moura Google Scholar
Simões, Ricardo Santos Autor UNIFESP Google Scholar
Arantes, Rosa Maria Esteves Google Scholar
Rachid, Milene Alvarenga Google Scholar
Silva, Regildo Marcio Goncalves da Google Scholar
Mendonca, Fabio de Souza Google Scholar
Evencio-Neto, Joaquim Google Scholar
Medeiros, Juliana Pinto de Google Scholar
Institution Univ Fed Rural Pernambuco
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
UNESP
Abstract PURPOSE: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with 5% BPT essential oil-based ointment in rats.METHODS: Twenty rats, male, of adult age, were submitted to skin surgery on the right (RA) and left antimeres (LA) of the thoracic region. They were divided into two groups: control (RA - wounds receiving daily topical application of vaseline and lanolin) and treated (LA - wounds treated daily with the topical ointment). the skin region with wounds were collected at days 4, 7, 14 and 21 after surgery. Those were fixed in 10% formaldehyde and later processed for paraffin embedding. Sections were obtained and stained by H.E for histopathology analysis. the degree of epithelial contraction was measured and mast cell concentration were also evaluated.RESULTS: the treated group showed higher mast cell concentrations (p<0.05) associated with increased contraction at day 7 and 14 respectively.CONCLUSION: Ointment containing 5% Brazilian pepper tree oil increases mast cell concentration and promotes skin wound contraction in rats.
Keywords Wound Healing
Phytotherapy
Mast Cells
Skin
Rats
Language English
Sponsor Pernambuco Research Foundation (FACEPE)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2015-04-01
Published in Acta Cirurgica Brasileira. São Paulo: Acta Cirurgica Brasileira, v. 30, n. 4, p. 289-295, 2015.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 289-295
Origin http://dx.doi.org/10.1590/S0102-865020150040000008
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000353700300008
SciELO ID S0102-865020150040000008 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/38920

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