Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis

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dc.contributor.author Nucci, Leopoldo P. [UNIFESP]
dc.contributor.author Silva, Helio R.
dc.contributor.author Giampaoli, Viviana
dc.contributor.author Mamani, Javier B.
dc.contributor.author Nucci, Mariana P.
dc.contributor.author Gamarra, Lionel F. [UNIFESP]
dc.date.accessioned 2016-01-24T14:40:14Z
dc.date.available 2016-01-24T14:40:14Z
dc.date.issued 2015-03-13
dc.identifier http://dx.doi.org/10.1186/s13287-015-0015-3
dc.identifier.citation Stem Cell Research & Therapy. London: Biomed Central Ltd, v. 6, 13 p., 2015.
dc.identifier.issn 1757-6512
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38883
dc.description.abstract Introduction: Although there is an increase in clinical trials assessing the efficacy of cell therapy in structural and functional regeneration after stroke, there are not enough data in the literature describing the best cell type to be used, the best route, and also the best nanoparticle to analyze these stem cells in vivo. This review analyzed published data on superparamagnetic iron oxide nanoparticle (SPION)-labeled stem cells used for ischemic stroke therapy.Method: We performed a systematic review and meta-analysis of data from experiments testing the efficacy of cellular treatment with SPION versus no treatment to improve behavioral or modified neural scale outcomes in animal models of stroke by the Cochrane Collaboration and indexed in EMBASE, PubMed, and Web of Science since 2000. To test the impact of study quality and design characteristics, we used random-effects meta-regression. in addition, trim and fill were used to assess publication bias.Results: the search retrieved 258 articles. After application of the inclusion criteria, 24 reports published between January 2000 and October 2014 were selected. These 24 articles were analyzed for nanoparticle characteristics, stem cell types, and efficacy in animal models.Conclusion: This study highlights the therapeutic role of stem cells in stroke and emphasizes nanotechnology as an important tool for monitoring stem cell migration to the affected neurological locus. en
dc.description.sponsorship Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship FAPEG
dc.format.extent 13
dc.language.iso eng
dc.publisher Biomed Central Ltd
dc.relation.ispartof Stem Cell Research & Therapy
dc.rights Acesso aberto
dc.title Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis en
dc.type Resenha
dc.contributor.institution Hosp Israelita Albert Einstein
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Santa Casa Misericordia São Paulo
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Hosp Israelita Albert Einstein, BR-05651901 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, BR-04021001 São Paulo, SP, Brazil
dc.description.affiliation Santa Casa Misericordia São Paulo, BR-01221020 São Paulo, SP, Brazil
dc.description.affiliation Univ São Paulo, Inst Matemat & Estat, BR-05508090 São Paulo, SP, Brazil
dc.description.affiliation Univ São Paulo, LIM44, BR-05403000 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, BR-04021001 São Paulo, SP, Brazil
dc.identifier.file WOS000354165400001.pdf
dc.identifier.doi 10.1186/s13287-015-0015-3
dc.description.source Web of Science
dc.identifier.wos WOS:000354165400001



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