Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis

Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis

Author Nucci, Leopoldo P. Autor UNIFESP Google Scholar
Silva, Helio R. Google Scholar
Giampaoli, Viviana Google Scholar
Mamani, Javier B. Google Scholar
Nucci, Mariana P. Google Scholar
Gamarra, Lionel F. Autor UNIFESP Google Scholar
Institution Hosp Israelita Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Santa Casa Misericordia São Paulo
Universidade de São Paulo (USP)
Abstract Introduction: Although there is an increase in clinical trials assessing the efficacy of cell therapy in structural and functional regeneration after stroke, there are not enough data in the literature describing the best cell type to be used, the best route, and also the best nanoparticle to analyze these stem cells in vivo. This review analyzed published data on superparamagnetic iron oxide nanoparticle (SPION)-labeled stem cells used for ischemic stroke therapy.Method: We performed a systematic review and meta-analysis of data from experiments testing the efficacy of cellular treatment with SPION versus no treatment to improve behavioral or modified neural scale outcomes in animal models of stroke by the Cochrane Collaboration and indexed in EMBASE, PubMed, and Web of Science since 2000. To test the impact of study quality and design characteristics, we used random-effects meta-regression. in addition, trim and fill were used to assess publication bias.Results: the search retrieved 258 articles. After application of the inclusion criteria, 24 reports published between January 2000 and October 2014 were selected. These 24 articles were analyzed for nanoparticle characteristics, stem cell types, and efficacy in animal models.Conclusion: This study highlights the therapeutic role of stem cells in stroke and emphasizes nanotechnology as an important tool for monitoring stem cell migration to the affected neurological locus.
Language English
Sponsor Instituto Israelita de Ensino e Pesquisa Albert Einstein
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
FAPEG
Date 2015-03-13
Published in Stem Cell Research & Therapy. London: Biomed Central Ltd, v. 6, 13 p., 2015.
ISSN 1757-6512 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 13
Origin http://dx.doi.org/10.1186/s13287-015-0015-3
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000354165400001
URI http://repositorio.unifesp.br/handle/11600/38883

Show full item record




File

Name: WOS000354165400001.pdf
Size: 1.704Mb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account