Influence of Microelement Concentration on the Intensity of Alcohol Withdrawal Syndrome

Influence of Microelement Concentration on the Intensity of Alcohol Withdrawal Syndrome

Author Prior, Pedro Luis Autor UNIFESP Google Scholar
Vaz, Marta Jezierski Google Scholar
Ramos, Anna Carolina Autor UNIFESP Google Scholar
Fernandes Galduroz, Jose Carlos Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ctr Referencia Tratamento Alcool Tabaco & Outras
Abstract Aims: To establish a nutritional and constitutional profile concerning the micronutrient plasma concentration of patients who suffer from AWS. Method: Observational case control study to determine whether patients who exhibited symptoms of AWS (N = 60) had micronutrient plasmatic concentration deficiencies when compared with healthy controls (N = 34). Results: There were statistically significant differences between the concentrations of nutrients that are correlated with glutamate hyperactivity (zinc, magnesium and folate/vitamin B12/homocysteine). Conclusion: Evidence from literature and our experiment suggests that brain activity, especially the glutamatergic system, might be directly involved in micronutrient concentrations. Therefore, their supplementation to the AWS patient might improve symptom evolution.
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Associacao Fundo de Incentivo a Pesquisa (AFIP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2012/06731-4
Date 2015-03-01
Published in Alcohol and Alcoholism. Oxford: Oxford Univ Press, v. 50, n. 2, p. 152-156, 2015.
ISSN 0735-0414 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 152-156
Origin http://dx.doi.org/10.1093/alcalc/agu094
Access rights Closed access
Type Article
Web of Science ID WOS:000352161800006
URI http://repositorio.unifesp.br/handle/11600/38852

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