Ultrathin films of lipids to investigate the action of a flavonoid with cell membrane models

Ultrathin films of lipids to investigate the action of a flavonoid with cell membrane models

Autor Narducci Ferrreira, Joao Victor Autor UNIFESP Google Scholar
Grecco, Simone dos S. Autor UNIFESP Google Scholar
Lago, Joao Henrique G. Autor UNIFESP Google Scholar
Caseli, Luciano Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Understanding the role of natural compounds whose pharmaceutical activity is associated with cell membranes is fundamental to comprehending the biochemical processes that occur on membrane surfaces. in this work, we examined the action of 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one, known as quercetin, QCT, in lipid Langmuir monolayers at the air-water interface, which served as a model for half of a membrane. the surface pressure-area isotherms for 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipid monolayers exhibited a noticeable shift to higher areas in the presence of the flavonoid, which indicated the incorporation of QCT into the monolayer and expansion of the film. Also the flavonoid incorporation diminishes the monolayer surface elasticity for DPPC and causes a relative decrease of the intensity for C-H stretch bands, pointing to a disruption of the packed order of DPPC. These results can be associated to the interaction between QCT and cell membrane surfaces during biochemical processes, which may influence its pharmaceutical properties. (C) 2014 Elsevier B.V. All rights reserved.
Assunto Surface Infrared Spectroscopy
Langmuir monolayers
Air-water interface
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
nBioNet: Films and Sensors
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 2013/10213-1
CNPq: 470890/2012-6
Data 2015-03-01
Publicado em Materials Science & Engineering C-materials for Biological Applications. Amsterdam: Elsevier B.V., v. 48, p. 112-117, 2015.
ISSN 0928-4931 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 112-117
Fonte http://dx.doi.org/10.1016/j.msec.2014.11.061
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000348749200015
URI http://repositorio.unifesp.br/handle/11600/38837

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