Prevalence of allergic diseases and/or allergic sensitisation in children and adolescents with type 1 diabetes mellitus

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dc.contributor.author Vitta-Nova, H. [UNIFESP]
dc.contributor.author Spinola-Castro, A. M. [UNIFESP]
dc.contributor.author Garcia, F. E. [UNIFESP]
dc.contributor.author Sole, D. [UNIFESP]
dc.date.accessioned 2016-01-24T14:40:09Z
dc.date.available 2016-01-24T14:40:09Z
dc.date.issued 2015-03-01
dc.identifier http://dx.doi.org/10.1016/j.aller.2013.11.009
dc.identifier.citation Allergologia Et Immunopathologia. Barcelona: Elsevier Doyma Sl, v. 43, n. 2, p. 157-161, 2015.
dc.identifier.issn 0301-0546
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38822
dc.description.abstract Background: the prevalence of atopic diseases in children with type 1 diabetes mellitus (DM1) has been reported as lower. the aim of this study was to evaluate the prevalence of allergic diseases and allergic sensitisation in Brazilian children and adolescents with DM1.Patients and methods: 96 patients with DM1 (aged 4-18 years, 45 boys) followed for at least one year were evaluated for allergic disease through a detailed allergological anamnesis and skin prick tests (SPT) to inhalant allergens (Dermatophagoides pteronyssinus, D. farinae, Blomia tropicalis, Blattella germanica, Periplaneta americana, dog epithelium, cat epithelium, mix fungi), foods (cow's milk, egg-white, yolk, soy, wheat, corn), and positive (histamine 1 mg/ml) and negative (saline) controls. Wheals with a mean diameter of induration equal to or greater than 3 mm identified a positive SPT.Results: the prevalence values of rhinitis, asthma and atopic eczema (isolated or associated) were 68.0%, 59.1% and 44.4%, respectively. 20.6% of the patients had no allergic disease. 46.8% of the patients had been diagnosed with DM1 for at least four years and there was no relationship between the period of DM1 and the presence of allergic disease, nor of the gender. 48.0% patients were sensitised with predominance of D. pteronyssinus, B. topicalis and D. farinae. the frequency of positive SPT was significantly higher among patients with history of allergic disease (OR = 6.98, 95%CI: 2.60-18.74, p < 0.001).Conclusion: the prevalence of allergic diseases and sensitisation in patients with DM1 was higher than usually expected and deserves further investigation to identify possible causes for these findings and to evaluate their importance and influence on the metabolic control. (C) 2013 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved. en
dc.format.extent 157-161
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Allergologia Et Immunopathologia
dc.rights Acesso restrito
dc.subject Asthma en
dc.subject Allergic rhinitis en
dc.subject Atopic eczema en
dc.subject Type 1 diabetes mellitus en
dc.subject Allergy en
dc.subject Sensitisation en
dc.subject Atapy en
dc.subject Children en
dc.subject Adolescents en
dc.title Prevalence of allergic diseases and/or allergic sensitisation in children and adolescents with type 1 diabetes mellitus en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med UNIFESP, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med UNIFESP, Dept Pediat, Div Endocrinol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med UNIFESP, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med UNIFESP, Dept Pediat, Div Endocrinol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.aller.2013.11.009
dc.description.source Web of Science
dc.identifier.wos WOS:000352746400007



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