Impression cytology in the evaluation of ocular surface tumors: review article

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dc.contributor.author Barros, Jeison de Nadai [UNIFESP]
dc.contributor.author Araujo de Almeida, Simone Ribeiro [UNIFESP]
dc.contributor.author Lowen, Marcia Serva [UNIFESP]
dc.contributor.author Cunha, Marcelo Carvalho da
dc.contributor.author Gomes, José Álvaro Pereira [UNIFESP]
dc.date.accessioned 2016-01-24T14:40:07Z
dc.date.available 2016-01-24T14:40:07Z
dc.date.issued 2015-03-01
dc.identifier http://dx.doi.org/10.5935/0004-2749.20150033
dc.identifier.citation Arquivos Brasileiros de Oftalmologia. São Paulo: Consel Brasil Oftalmologia, v. 78, n. 2, p. 126-132, 2015.
dc.identifier.issn 0004-2749
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38805
dc.description.abstract Impression cytology (IC) has been widely used as a method for evaluating the ocular surface and superficial cells layers in the diagnosis and follow-up after treatment of several ocular surface tumors of both epithelial and melanocytic origin. Information regarding this can be found in the English-language literature since 1992. Using either cellulose acetate or Biopore membranes for specimen collection, a high correlation has been found between IC and tissue histology. Compared with exfoliative cytology with spatula, IC is less traumatic to the patient's eye, provides a precise location of the area being studied, and allows accurate observation of the cells the way they exist in vivo. the additional advantage of IC is the preservation of limbal stem cells responsible for continuous corneal epithelium renewal; these can be affected after incisional or excisional biopsy at the corneoscleral limbus, which is the most frequent site of appearance of tumors in the stratified epithelium. Treatment for ocular surface squamous neoplasia has historically included surgery, but nonsurgical interventions have also been adopted. Hence, in certain cases, ophthalmologists may prefer interventions less invasive than surgical biopsy such as of impression cytology for both initial diagnosis and therapeutic monitoring of treatment for ocular surface lesions. Nevertheless, it should be considered that IC may be less helpful if the results conflict with the clinical picture or if the clinical diagnosis is uncertain and results are negative. in such cases, surgical biopsy is required for accurate diagnosis. the purpose of this review is to examine the published literature on the utilization of IC for the diagnosis and management of ocular surface tumors and to discuss the requirement for further investigation on the subject. en
dc.format.extent 126-132
dc.language.iso eng
dc.publisher Consel Brasil Oftalmologia
dc.relation.ispartof Arquivos Brasileiros de Oftalmologia
dc.rights Acesso aberto
dc.subject Conjunctiva en
dc.subject Cornea en
dc.subject Limbus corneae en
dc.subject Conjunctival neoplasms/diagnosis en
dc.subject Eye neoplasms en
dc.subject Cytodiagnosis en
dc.subject Cytological techniques en
dc.subject Diagnostic techniques, ophthalmological en
dc.subject Review en
dc.title Impression cytology in the evaluation of ocular surface tumors: review article en
dc.title.alternative Citologia de impressão na avaliação de tumores da superfície ocular: artigo de revisão pt
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Clin Olhos Dr Moacir Cunha
dc.description.affiliation Universidade Federal de São Paulo, Dept Ophthalmol & Visual Sci, São Paulo, SP, Brazil
dc.description.affiliation Clin Olhos Dr Moacir Cunha, São Paulo, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pathol, São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ophthalmol & Visual Sci, São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pathol, São Paulo, SP, Brazil
dc.identifier.file S0004-27492015000200016.pdf
dc.identifier.scielo S0004-27492015000200016
dc.identifier.doi 10.5935/0004-2749.20150033
dc.description.source Web of Science
dc.identifier.wos WOS:000354050800016



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