Impression cytology in the evaluation of ocular surface tumors: review article

Impression cytology in the evaluation of ocular surface tumors: review article

Alternative title Citologia de impressão na avaliação de tumores da superfície ocular: artigo de revisão
Author Barros, Jeison de Nadai Autor UNIFESP Google Scholar
Araujo de Almeida, Simone Ribeiro Autor UNIFESP Google Scholar
Lowen, Marcia Serva Autor UNIFESP Google Scholar
Cunha, Marcelo Carvalho da Google Scholar
Gomes, José Álvaro Pereira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Clin Olhos Dr Moacir Cunha
Abstract Impression cytology (IC) has been widely used as a method for evaluating the ocular surface and superficial cells layers in the diagnosis and follow-up after treatment of several ocular surface tumors of both epithelial and melanocytic origin. Information regarding this can be found in the English-language literature since 1992. Using either cellulose acetate or Biopore membranes for specimen collection, a high correlation has been found between IC and tissue histology. Compared with exfoliative cytology with spatula, IC is less traumatic to the patient's eye, provides a precise location of the area being studied, and allows accurate observation of the cells the way they exist in vivo. the additional advantage of IC is the preservation of limbal stem cells responsible for continuous corneal epithelium renewal; these can be affected after incisional or excisional biopsy at the corneoscleral limbus, which is the most frequent site of appearance of tumors in the stratified epithelium. Treatment for ocular surface squamous neoplasia has historically included surgery, but nonsurgical interventions have also been adopted. Hence, in certain cases, ophthalmologists may prefer interventions less invasive than surgical biopsy such as of impression cytology for both initial diagnosis and therapeutic monitoring of treatment for ocular surface lesions. Nevertheless, it should be considered that IC may be less helpful if the results conflict with the clinical picture or if the clinical diagnosis is uncertain and results are negative. in such cases, surgical biopsy is required for accurate diagnosis. the purpose of this review is to examine the published literature on the utilization of IC for the diagnosis and management of ocular surface tumors and to discuss the requirement for further investigation on the subject.
Keywords Conjunctiva
Limbus corneae
Conjunctival neoplasms/diagnosis
Eye neoplasms
Cytological techniques
Diagnostic techniques, ophthalmological
Language English
Date 2015-03-01
Published in Arquivos Brasileiros de Oftalmologia. São Paulo: Consel Brasil Oftalmologia, v. 78, n. 2, p. 126-132, 2015.
ISSN 0004-2749 (Sherpa/Romeo, impact factor)
Publisher Consel Brasil Oftalmologia
Extent 126-132
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000354050800016
SciELO ID S0004-27492015000200016 (statistics in SciELO)

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