High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results

High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results

Author Salum, Giovanni Abrahão Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Pan, Pedro Mario Autor UNIFESP Google Scholar
Moriyama, Tais Silveira Autor UNIFESP Google Scholar
Graeff-Martins, Ana Soledade Google Scholar
Tamanaha, Ana Carina Autor UNIFESP Google Scholar
Alvarenga, Pedro Google Scholar
Krieger, Fernanda Valle Google Scholar
Fleitlich-Bilyk, Bacy Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Sato, Joao Ricardo Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Polanczyk, Guilherme Vanoni Google Scholar
Brentani, Helena Google Scholar
Mari, Jair de Jesus Autor UNIFESP Google Scholar
Rosario-Campos, Maria Conceicao do Autor UNIFESP Google Scholar
Manfro, Gisele Gus Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Mercadante, Marcos Tomanik Autor UNIFESP Google Scholar
Miguel, Euripedes Constantino Google Scholar
Rohde, Luis Augusto Google Scholar
Institution Natl Inst Dev Psychiat Children & Adolescents INC
Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Universidade Federal do ABC (UFABC)
Abstract The objective of this study is to present the rationale, methods, design and preliminary results from the High Risk Cohort Study for the Development of Childhood Psychiatric Disorders. We describe the sample selection and the components of each phases of the study, its instruments, tasks and procedures. Preliminary results are limited to the baseline phase and encompass: (i) the efficacy of the oversampling procedure used to increase the frequency of both child and family psychopathology; (ii) interrater reliability and (iii) the role of differential participation rate. A total of 9937 children from 57 schools participated in the screening procedures. From those 2512 (random =958; high risk =1554) were further evaluated with diagnostic instruments. the prevalence of any child mental disorder in the random strata and high-risk strata was 19.9% and 29.7%. the oversampling procedure was successful in selecting a sample with higher family rates of any mental disorders according to diagnostic instruments. Interrater reliability (kappa) for the main diagnostic instrument range from 0.72 (hyperkinetic disorders) to 0.84 (emotional disorders). the screening instrument was successful in selecting a sub-sample with high risk for developing mental disorders. This study may help advance the field of child psychiatry and ultimately provide useful clinical information. Copyright (c) 2014 John Wiley & Sons, Ltd.
Keywords longitudinal
development
genetics
psychiatry
cohort
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS, Research Support Foundation from the State of Rio Grande do Sul)
Grant number CNPq: 573974/2008-0
FAPESP: 2008/57896-8
CNPq: 302463/2011-9
Date 2015-03-01
Published in International Journal of Methods in Psychiatric Research. Hoboken: Wiley-Blackwell, v. 24, n. 1, p. 58-73, 2015.
ISSN 1049-8931 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 58-73
Origin http://dx.doi.org/10.1002/mpr.1459
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000350640300005
URI http://repositorio.unifesp.br/handle/11600/38778

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