Study of Acetylsalicylic Acid Adsorption Using Molecular Sieves

Study of Acetylsalicylic Acid Adsorption Using Molecular Sieves

Author Assumpcao, G. A. Autor UNIFESP Google Scholar
Poco, J. G. R. Google Scholar
Fernandez-Felisbino, R. Autor UNIFESP Google Scholar
Cardoso, D. Google Scholar
Gomes, E. L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Ctr FEI
Universidade Federal de São Carlos (UFSCar)
Abstract Molecular sieves can be used as a host matrix to encapsulate several drugs. Here, we studied the adsorption of acetylsalicylic acid (ASA) in HUS-Y, HZSM-5 and silicalite-1 zeolites, as well as in the mesoporous sieve Si-MCM-41, and compared their adsorption capacities. the materials used generally presented good performance for ASA adsorption. Among the zeolites studied, HZSM-5 adsorbed large amounts of drug than the others. the Si-MCM-41 samples synthesized with fumed silica presented better adsorption performance than those synthesized with tetraethyl orthosilicate. the best mesoporous sample for adsorption synthesized with fumed silica was chosen for the kinetic assay. the adsorption kinetics of ASA for this sample fitted well to a second-order model. the initial loading rate and diffusion coefficient for the ASA-mesoporous sieve system were 0.153% (mg ASA)/(mg solid/minute) and 5.02 x 10(-17) m(2)/s, respectively. the materials were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and nitrogen physisorption.
Language English
Date 2015-02-01
Published in Adsorption Science & Technology. Brentwood: Multi-science Publ Co Ltd, v. 33, n. 2, p. 203-221, 2015.
ISSN 0263-6174 (Sherpa/Romeo, impact factor)
Publisher Multi-science Publ Co Ltd
Extent 203-221
Access rights Closed access
Type Article
Web of Science ID WOS:000352264600011

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