Different MOG(35-55) concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-beta in mice CNS despite unchanged clinical course

Different MOG(35-55) concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-beta in mice CNS despite unchanged clinical course

Author Dias, Alyria Teixeira Google Scholar
Ribeiro De Castro, Sandra Bertelli Google Scholar
De Souza Alves, Caio Cesar Google Scholar
Mesquita, Felipe Pereira Google Scholar
Visona De Figueiredo, Nathalia Stela Google Scholar
Evangelista, Marcilene Gomes Google Scholar
Marques Nogueira Castanon, Maria Christina Google Scholar
Juliano, Maria Aparecida Autor UNIFESP Google Scholar
Ferreira, Ana Paula Google Scholar
Institution Univ Fed Juiz de Fora
Fed Univ Valleys Jequitinhonha & Mucuri
Universidade Federal de São Paulo (UNIFESP)
Abstract Multiple sclerosis (MS) shows distinct clinical courses. Experimental autoimmune encephalomyelitis (EAE), a model to study multiple sclerosis, can be induced by different protocols, which show distinct cytokine and antibody production. the factors involved in this heterogeneity remain unclear. the relevance of MUG concentration in triggering a regulatory response in the chronic model of EAE is imprecise. the aim of this study was investigate if 100 or 300 mu g of MOG(35-55) could induce different EAE profiles. Modifications in the concentration of MUG were able to change the patterns of chemokines, cytokines, percentage of cells, inflammatory infiltrate and the development of a regulatory response. However, these changes were unable to modify the intensity of response, which explains the chronic progression of the disease in both concentrations. the results presented in this study contribute to understanding the intricate mechanisms that trigger EAE and provide insights into the pathogenesis of various forms of MS. (C) 2015 Elsevier Inc. All rights reserved.
Keywords Multiple sclerosis
Animal model
Autoimmunity
MOG(35-55)
Cytokines
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number CNPq: 481459/2009-0
CNPq: 303369/2009-4
CNPq: 306575/2012-4
CNPq: 470768/2013-4
FAPEMIG: 02236/10
FAPEMIG: PPM 0216/10
FAPEMIG: 00269-14
CAPES: PNPD-2882/2011
Date 2015-02-01
Published in Cellular Immunology. San Diego: Academic Press Inc Elsevier Science, v. 293, n. 2, p. 87-94, 2015.
ISSN 0008-8749 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 87-94
Origin http://dx.doi.org/10.1016/j.cellimm.2014.12.009
Access rights Closed access
Type Article
Web of Science ID WOS:000350089900005
URI http://repositorio.unifesp.br/handle/11600/38688

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account