Epilepsy-induced electrocardiographic alterations following cardiac ischemia and reperfusion in rats

Epilepsy-induced electrocardiographic alterations following cardiac ischemia and reperfusion in rats

Author Tavares, Jose Gustavo P. Autor UNIFESP Google Scholar
Vasques, E. R. Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Cabral, Francisco Romero Google Scholar
Torres, Laila Brito Google Scholar
Menezes-Rodrigues, Francisco Sandro Autor UNIFESP Google Scholar
Jurkiewicz, Aron Autor UNIFESP Google Scholar
Caricati-Neto, Afonso Autor UNIFESP Google Scholar
Godoy, Carlos Marcelo G. Autor UNIFESP Google Scholar
Gomes da Silva, Sergio Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Iguacu
Fac Minas
Universidade de São Paulo (USP)
Hosp Israelita Albert Einstein
Univ Mogi das Cruzes
Abstract The present study evaluated electrocardiographic alterations in rats with epilepsy submitted to an acute myocardial infarction (AMI) model induced by cardiac ischemia and reperfusion. Rats were randomly divided into two groups: control (n=12) and epilepsy (n=14). It was found that rats with epilepsy presented a significant reduction in atrioventricular block incidence following the ischemia and reperfusion procedure. in addition, significant alterations were observed in electrocardiogram intervals during the stabilization, ischemia, and reperfusion periods of rats with epilepsy compared to control rats. It was noted that rats with epilepsy presented a significant increase in the QRS interval during the stabilization period in relation to control rats (P<0.01). During the ischemia period, there was an increase in the QRS interval (P<0.05) and a reduction in the P wave and QT intervals (P<0.05 for both) in rats with epilepsy compared to control rats. During the reperfusion period, a significant reduction in the QT interval (P<0.01) was verified in the epilepsy group in relation to the control group. Our results indicate that rats submitted to an epilepsy model induced by pilocarpine presented electrical conductivity alterations of cardiac tissue, mainly during an AMI episode.
Keywords Epilepsy
Acute myocardial infarction
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Instituto Nacional de Neurociencia Translacional (INNT)
Grant number FAPESP: 09/069534
Date 2015-02-01
Published in Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 48, n. 2, p. 140-145, 2015.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 140-145
Origin http://dx.doi.org/10.1590/1414-431X20144311
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000351598300006
SciELO ID S0100-879X2015000200140 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/38669

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