Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring

Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring

Author Mennitti, Lais V. Autor UNIFESP Google Scholar
Oliveira, Juliana L. Autor UNIFESP Google Scholar
Morais, Carina A. Autor UNIFESP Google Scholar
Estadella, Debora Autor UNIFESP Google Scholar
Oyama, Lila M. Autor UNIFESP Google Scholar
Nascimento, Claudia M. Oller do Autor UNIFESP Google Scholar
Pisani, Luciana P. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract During pregnancy and/or lactation, maternal nutrition is related to the adequate development of the fetus, newborn and future adult, likely by modifications in fetal programming and epigenetic regulation. Fetal programming is characterized by adaptive responses to specific environmental conditions during early life stages, which may alter gene expression and permanently affect the structure and function of several organs and tissues, thus influencing the susceptibility to metabolic disorders. Regarding lipid metabolism during the first two trimesters of pregnancy, the maternal body accumulates fat, whereas in late pregnancy, the lipolytic activity in the maternal adipose tissue is increased. However, an excess or deficiency of certain fatty acids may lead to adverse consequences to the fetuses and newborns. Fetal exposure to trans fatty acids appears to promote early deleterious effects in the offspring's health, thereby increasing the individual risk for developing metabolic diseases throughout life. Similarly, the maternal intake of saturated fatty acids seems to trigger alterations in the liver and adipose tissue function associated with insulin resistance and diabetes. the polyunsaturated fatty acids (PUFAs), particularly long-chain PUFAs (long-chain PUFA-arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid), play an important and beneficial physiologic role in the offspring who receive this fatty acid during critical periods of development. Therefore, the maternal nutritional condition and fatty acid intake during pregnancy and/or lactation are critical factors that are strongly associated with normal fetal and postnatal development, which influence the modifications in fetal programming and in the individual risk for developing metabolic diseases throughout life. (C) 2015 Elsevier Inc. All rights reserved.
Keywords Fatty acids
Programming
Pregnancy
Lactation
Metabolism
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2015-02-01
Published in Journal of Nutritional Biochemistry. New York: Elsevier B.V., v. 26, n. 2, p. 99-111, 2015.
ISSN 0955-2863 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 99-111
Origin http://dx.doi.org/10.1016/j.jnutbio.2014.10.001
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000349578300001
URI http://repositorio.unifesp.br/handle/11600/38647

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