Aminolevulinic acid with gold nanoparticles: a novel theranostic agent for atherosclerosis

Aminolevulinic acid with gold nanoparticles: a novel theranostic agent for atherosclerosis

Author Goncalves, Karina de Oliveira Autor UNIFESP Google Scholar
Silva, Monica Nascimento da Autor UNIFESP Google Scholar
Sicchieri, Leticia Bonfante Google Scholar
Silva, Flávia Rodrigues de Oliveira Google Scholar
Matos, Ricardo Almeida de Autor UNIFESP Google Scholar
Courrol, Lilia Coronato Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Inst Pesquisas Energet & Nucl
Abstract In this study, 5-aminolevulinic acid (ALA) gold nanoparticles (ALA:AuNPs) functionalized with polyethylene glycol (PEG) were synthesized and administered to rabbits to evaluate their use in clinical practice as theranostic agents for atherosclerosis. This was done by measuring the porphyrin fluorescence extracted from the rabbits' blood and feces. An increase in blood and feces porphyrin emission after ALA: AuNP administration suggests that ALA was incorporated by gold nanoparticles, its structure was preserved, and a rapid conversion into endogenous porphyrins occurred, overloading the synthetic pathway that led to protoporphyrin IX (PPIX) accumulation. This finding indicated that this method can aid in the early diagnosis and therapy of atherosclerosis with high sensitivity.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2010/016544-1
Date 2015-01-01
Published in Analyst. Cambridge: Royal Soc Chemistry, v. 140, n. 6, p. 1974-1980, 2015.
ISSN 0003-2654 (Sherpa/Romeo, impact factor)
Publisher Royal Soc Chemistry
Extent 1974-1980
Origin http://dx.doi.org/10.1039/c4an02166e
Access rights Closed access
Type Article
Web of Science ID WOS:000350573400031
URI http://repositorio.unifesp.br/handle/11600/38596

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