Low-level laser therapy in IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendon

Low-level laser therapy in IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendon

Autor Jesus, Julio Fernandes de Autor UNIFESP Google Scholar
Spadacci-Morena, Diva Denelle Google Scholar
Anjos Rabelo, Nayra Deise dos Google Scholar
Pinfildi, Carlos Eduardo Autor UNIFESP Google Scholar
Fukuda, Thiago Yukio Google Scholar
Plapler, Helio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Inst Butantan
Univ Nove Julho UNINOVE
ISCMSP
Resumo This study evaluated IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendons treated with low-level laser therapy (LLLT). Sixty-five male Wistar rats were used. Sixty were submitted to a direct injury on Achilles tendon and then distributed into six groups: LASER 1 (a single LLLT application), LASER 3 (three LLLT applications), and LASER 7 (seven LLLT applications) and Sham 1, 3, and 7 (the same injury but LLLT applications were simulated). the five remaining animals were allocated at control group (no procedure performed). LLLT (780 nm) was applied with 70 mW of mean power and 17.5 J/cm(2) of fluency for 10 s, once a day. the tendons were surgically removed and assessed immunohistochemically for IL-1 beta, COX-2, and PGE2. in comparisons with control (IL-1 beta: 100.5 +/- 92.5 / COX-2: 180.1 +/- 97.1 / PGE2: 187.8 +/- 128.8) IL-1 beta exhibited (mean +/- SD) near-normal level (p > 0.05) at LASER 3 (142.0 +/- 162.4). COX-2 and PGE2 exhibited near-normal levels (p > 0.05) at LASER 3 (COX-2: 176.9 +/- 75.4 / PGE2: 297.2 +/- 259.6) and LASER 7 (COX-2: 259.2 +/- 190.4 / PGE2: 587.1 +/- 409.7). LLLT decreased Achilles tendon's inflammatory process.
Assunto Achilles tendon
Collagen
Inflammation
Low-level laser therapy
Tendinopathy
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 2011/00979-1
Data 2015-01-01
Publicado em Lasers in Medical Science. London: Springer London Ltd, v. 30, n. 1, p. 153-158, 2015.
ISSN 0268-8921 (Sherpa/Romeo, fator de impacto)
Editor Springer
Extensão 153-158
Fonte http://dx.doi.org/10.1007/s10103-014-1636-y
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000348297900021
URI http://repositorio.unifesp.br/handle/11600/38573

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