Late-Onset Sepsis in very Low Birth Weight Infants: A Brazilian Neonatal Research Network Study

Late-Onset Sepsis in very Low Birth Weight Infants: A Brazilian Neonatal Research Network Study

Autor Suppo de Souza Rugolo, Ligia Maria Google Scholar
Bentlin, Maria Regina Google Scholar
Mussi-Pinhata, Marisa Google Scholar
Branco de Almeida, Maria Fernanda Autor UNIFESP Google Scholar
Andrade Lopes, Jose Maria de Google Scholar
Martins Marba, Sergio Tadeu Google Scholar
Fiori, Humberto Holmer Google Scholar
Procianoy, Renato Soibelmann Google Scholar
Leone, Clea Rodrigues Google Scholar
Brazilian Network Neonatal Res Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Fundacao Oswaldo Cruz
Pontificia Univ Catolica Rio Grande do Sul
Univ Fed Rio Grande do Sul
Resumo Background: Late-onset sepsis (LOS) is an important cause of morbidity and mortality in very low birth weight (VLBW) infants.Aim: To determine the incidence, risk factors and etiology of LOS.Methods: LOS was investigated in a multicenter prospective cohort of infants at eight public university neonatal intensive care units (NICUs). Inclusion criteria included inborn, 23-33 weeks of gestational age, 400-1499 g birth weight, who survived >3 days.Results: of 1507 infants, 357 (24%) had proven LOS and 345 (23%) had clinical LOS. Infants with LOS were more likely to die. the majority of infections (76%) were caused by Gram-positive organisms. Independent risk factors for proven LOS were use of central venous catheter and mechanical ventilation, age at the first feeding and number of days on parenteral nutrition and on mechanical ventilation.Conclusion: LOS incidence and mortality are high in Brazilian VLBW infants. Most risk factors are associated with routine practices at NICU.
Assunto Sepsis
newborn infant
very low birth weight
Idioma Inglês
Data 2014-12-01
Publicado em Journal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 60, n. 6, p. 415-421, 2014.
ISSN 0142-6338 (Sherpa/Romeo, fator de impacto)
Editor Oxford Univ Press
Extensão 415-421
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000346035900003

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