Nerve Regeneration: Is There an Alternative to Nervous Graft?

Nerve Regeneration: Is There an Alternative to Nervous Graft?

Author Sabongi, Rodrigo Guerra Autor UNIFESP Google Scholar
Lucas Martins de Rizzo, Luiz Augusto Autor UNIFESP Google Scholar
Fernandes, Marcela Autor UNIFESP Google Scholar
Valente, Sandra Gomes Autor UNIFESP Google Scholar
Gomes dos Santos, Joao Baptista Autor UNIFESP Google Scholar
Faloppa, Flavio Autor UNIFESP Google Scholar
Leite, Vilnei Mattioli Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background in nerve injury with nervous gap, no restitution method was found better than the autograft, however, it has the disadvantage of damaging a normal nerve to be used as a graft. Platelet-rich plasma (PRP) is a possible filler material for vein grafts used as conduits for nerve regeneration, preventing its collapse, and providing growth factors and osteoconductive proteins.Methods Isogenic rats were randomly divided into three groups. They received nerve autografts (GRF), PRP-containing vein grafts or a sham operation. Outcomes were evaluated by the sciatic functional index (SFI), morphometric, and morphologic analyses of the nerve distal to the lesion, and the number of spinal cord motoneurons positive for retrograde Fluoro-Gold (Santa Cruz Biotechnology, Inc., Dallas, TX) tracer.Results the PRP and GRF groups had lower SFI values than the control animals throughout the postoperative period. the SFI was significantly higher in the PRP group than the GRF group at 90 days postoperatively (p = 0.011). Fiber diameter and number of motoneurons were significantly decreased in both the PRP and GRF groups, as compared with the control.Conclusion PRP within a vein conduit may be an effective alternative or adjuvant to GRF, the current preferred treatment for nerve injury with a nerve gap, and further investigations are required to fully define the role of PRP in nerve regeneration.
Keywords nerve regeneration
platelet-rich plasma
nerve graft
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2010/52624-0
Date 2014-11-01
Published in Journal of Reconstructive Microsurgery. New York: Thieme Medical Publ Inc, v. 30, n. 9, p. 607-616, 2014.
ISSN 0743-684X (Sherpa/Romeo, impact factor)
Publisher Thieme Medical Publ Inc
Extent 607-616
Origin http://dx.doi.org/10.1055/s-0034-1372477
Access rights Closed access
Type Article
Web of Science ID WOS:000343192000003
URI http://repositorio.unifesp.br/handle/11600/38420

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