Heart rate variability and cardiorespiratory coupling in obstructive sleep apnea: elderly compared with young

Heart rate variability and cardiorespiratory coupling in obstructive sleep apnea: elderly compared with young

Author Trimer, R. Google Scholar
Cabidu, R. Google Scholar
Sampaio, L. L. M. Google Scholar
Stirbulov, R. Google Scholar
Poiares, D. Autor UNIFESP Google Scholar
Guizilini, S. Autor UNIFESP Google Scholar
Bianchi, A. M. Google Scholar
Costa, F. S. M. Google Scholar
Mendes, R. G. Google Scholar
Delfino, A. Google Scholar
Arena, R. Google Scholar
Borghi-Silva, A. Google Scholar
Institution Universidade Federal de São Carlos (UFSCar)
Politecn Milan
Nove Julho Univ
Uni Santa Casa Misericordia São Paulo
Universidade Federal de São Paulo (UNIFESP)
Sleep Inst Sao Carlos
Univ Illinois
Abstract Introduction: Aging is known to be a major contributing factor to the increased risk of obstructive sleep apnea (OSA). With aging, breathing undergoes significant changes during sleep, increasing the prevalence of apnea events, which affects heart rate variability (HRV) and cardiorespiratory coupling (CRC).Objectives: To compare HRV and CRC during wakefulness and sleep between young and elderly patients with and without OSA; and to determine whether the presence of OSA in young and elderly patients has a different impact on HRV and CRC during sleep.Methods: One hundred subjects, 50 young (mean age, 27 +/- 9; 20 normal and 30 OSA) and 50 elderly (mean age, 65 +/- 7; 20 normal and 30 OSA), underwent polysomnography. Spectral, cross-spectrum, and HRV parameters were analyzed during wakefulness and sleep.Results: the spectral analysis indicated that age affected HRV, with higher values of low frequency (P < 0.05) in elderly subjects during wakefulness and an interaction between the presence of OSA and age. OSA influenced HRV during sleep with lower LF/HF ratios during stage 2 (S2) and rapid eye movement (REM) sleep (P < 0.05), with an interaction between the presence of OSA and age in REM sleep. Elderly patients had significantly lower percent tachogram power coherent with respiration (%TPCR) during wakefulness (P < 0.05), and OSA led to lower %TPCR during S2.Conclusions: Age and OSA have an unfavorable impact on HRV, with reduced autonomic modulation during wakefulness, S2, and REM sleep. Age affects CRC during wakefulness and the presence of OSA affects CRC during sleep. (C) 2014 Elsevier B.V. All rights reserved.
Keywords Obstructive sleep apnea
Heart rate variability
Cardiorespiratory coupling
Elderly
Young
Age
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2009/01842-0
CAPES: 12883-12-3
Date 2014-11-01
Published in Sleep Medicine. Amsterdam: Elsevier B.V., v. 15, n. 11, p. 1324-1331, 2014.
ISSN 1389-9457 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1324-1331
Origin http://dx.doi.org/10.1016/j.sleep.2014.05.028
Access rights Closed access
Type Article
Web of Science ID WOS:000344237200009
URI http://repositorio.unifesp.br/handle/11600/38411

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