Age effects on the default mode and control networks in typically developing children

Age effects on the default mode and control networks in typically developing children

Author Sato, Joao Ricardo Autor UNIFESP Google Scholar
Salum, Giovanni Abrahao Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Picon, Felipe Almeida Google Scholar
Pan, Pedro Mario Autor UNIFESP Google Scholar
Vieira, Gilson Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Hoexter, Marcelo Queiroi Autor UNIFESP Google Scholar
Anes, Mauricio Google Scholar
Moura, Luciana Monteiro Autor UNIFESP Google Scholar
Gomes Del'Aquilla, Marco Antonio Autor UNIFESP Google Scholar
Amaro Junior, Edson Google Scholar
McGuire, Philip Google Scholar
Crossley, Nicolas Google Scholar
Lacerda, Acioly Autor UNIFESP Google Scholar
Rohde, Luis Augusto Google Scholar
Miguel, Euripedes Constantino Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Institution Universidade Federal do ABC (UFABC)
Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Kings Coll London
CNPq
Abstract Background: the investigation of neurodevelopment during late childhood and pre-adolescence has recently attracted a great deal of interest in the field of neuroimaging. One promising topic in this field is the formation of brain networks in healthy subjects. the integration between neural modules characterizes the ability of the network to process information globally. Although many fMRI-based neurodevelopment studies can be found in the literature, the analyses of very large samples (on the order of hundreds of subjects) that focus on the late childhood/pre-adolescence period and resting state fMRI are scarce, and most studies have focused solely on North American and European populations.Aims: in this study, we present a descriptive investigation of the developmental formation of the Default Mode Network and the Control Network based on a Brazilian, cross-sectional community sample of 447 typically developing subjects aged 7-15 years old.Methods: Resting state fMRI data were acquired using two MRI systems from the same manufacturer using the same acquisition parameters. We estimated the age effects on the strength of the links (between brain regions) and the network features (graph descriptors: degree and eigenvector centrality).Results: Our findings showed an increase in the antero-posterior connectivity in both studied networks during brain development. the graph analyses showed an increase in centrality with age for most regions in the Default Mode Network and the dorsal anterior and posterior cingulate, the right anterior insula and the left posterior temporal cortex in the Control Network.Conclusion: We conclude that the period of 7-15 years of age is crucial for the development of both the Default Mode and Control networks, with integration between the posterior and anterior neuronal modules and an increase in the centrality measures of the hub regions. (C) 2014 Elsevier B.V. All rights reserved.
Keywords Neurodevelopment
Brain networks
Neuroimaging
Graph theory
Healthy
Typical development
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Wellcome Trust
Grant number FAPESP: 573974/2008-0
FAPESP: 2013/10498-6
FAPESP: 2013/00506-1
Date 2014-11-01
Published in Journal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 58, p. 89-95, 2014.
ISSN 0022-3956 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 89-95
Origin http://dx.doi.org/10.1016/j.jpsychires.2014.07.004
Access rights Closed access
Type Article
Web of Science ID WOS:000342866200013
URI http://repositorio.unifesp.br/handle/11600/38401

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