Assessment of risk factors for earlier onset of sporadic Alzheimer's disease dementia

Assessment of risk factors for earlier onset of sporadic Alzheimer's disease dementia

Author Oliveira, Fabricio Ferreira de Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Chen, Elizabeth Suchi Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Pharmacological treatment has mild effects for patients with Alzheimer's disease dementia (AD); therefore, the search for modifiable risk factors is an important challenge. Though risk factors for AD are widely recognized, elements that influence the time of dementia onset have not been comprehensively reported. We aimed to investigate which risk factors might be related to the age of onset of AD in a sample of patients with highly variable educational levels, taking into account the Framingham risk scoring as the sole measure of vascular risk. Subjects and Methods: We included 209 consecutive late-onset AD patients to find out which factors among educational levels, coronary heart disease risk estimated by way of Framingham risk scores, history of head trauma or depression, surgical procedures under general anesthesia, family history of neurodegenerative diseases, gender, marital status and APOE haplotypes might be related to the age of dementia onset in this sample of patients with low mean schooling. Results: Mean age of AD onset was 73.38 +/- 6.5 years old, unaffected by schooling or family history of neurodegenerative diseases. Patients who were APOE-epsilon 4 carriers, married, or with history of depression, had earlier onset of AD, particularly when they were women. Coronary heart disease risk was marginally significant for later onset of AD. Conclusions: APOE haplotypes, marital status and history of depression were the most important factors to influence the age of AD onset in this sample. While midlife cerebrovascular risk factors may increase incidence of AD, they may lead to later dementia onset when present in late life.
Keywords Alzheimer disease
cerebrovascular disorders
educational status
neurodegenerative diseases
risk factors
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2014-11-01
Published in Neurology India. Mumbai: Medknow Publications & Media Pvt Ltd, v. 62, n. 6, p. 625-630, 2014.
ISSN 0028-3886 (Sherpa/Romeo, impact factor)
Publisher Medknow Publications & Media Pvt Ltd
Extent 625-630
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000348612400007

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