Plasma Cytokine Profile in Tropical Endomyocardial Fibrosis: Predominance of TNF-a, IL-4 and IL-10

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dc.contributor.author Bossa, Aline S.
dc.contributor.author Salemi, Vera M. C.
dc.contributor.author Ribeiro, Susan P.
dc.contributor.author Rosa, Daniela Santoro [UNIFESP]
dc.contributor.author Pinto Ferreira, Ludmila Rodrigues
dc.contributor.author Ferreira, Suzete C.
dc.contributor.author Nishiya, Anna Shoko
dc.contributor.author Mady, Charles
dc.contributor.author Kalil, Jorge
dc.contributor.author Cunha-Neto, Edecio
dc.date.accessioned 2016-01-24T14:38:00Z
dc.date.available 2016-01-24T14:38:00Z
dc.date.issued 2014-10-10
dc.identifier http://dx.doi.org/10.1371/journal.pone.0108984
dc.identifier.citation Plos One. San Francisco: Public Library Science, v. 9, n. 10, 5 p., 2014.
dc.identifier.issn 1932-6203
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38328
dc.description.abstract Background: the participation of immune/inflammatory mechanisms in the pathogenesis of tropical endomyocardial fibrosis (EMF) has been suggested by the finding of early blood and myocardial eosinophilia. However, the inflammatory activation status of late-stage EMF patients is still unknown.Methodology/Principal findings: We evaluated pro- and anti-inflammatory cytokine levels in plasma samples from late stage EMF patients. Cytokine levels of Tumor Necrosis Factor (TNF)-alpha, Interferon (IFN)-gamma, Interleukin (IL)-2, IL-4, IL-6, and IL-10 were assayed in plasma samples from 27 EMF patients and compared with those of healthy control subjects. All EMF patients displayed detectable plasma levels of at least one of the cytokines tested. We found that TNF-alpha, IL-6, IL-4, and IL-10 were each detected in at least 74% of tested sera, and plasma levels of IL-10, IL-4, and TNF-alpha were significantly higher than those of controls. Plasma levels of such cytokines positively correlated with each other.Conclusions/Significance: the mixed pro-and anti-inflammatory/Th2circulating cytokine profile in EMF is consistent with the presence of a persistent inflammatory stimulus. On the other hand, the detection of increased levels of TNF-alpha may be secondary to the cardiovascular involvement observed in these patients, whereas IL-4 and IL-10 may have been upregulated as a homeostatic mechanism to buffer both production and deleterious cardiovascular effects of pro-inflammatory cytokines. Further studies might establish whether these findings play a role in disease pathogenesis. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 5
dc.language.iso eng
dc.publisher Public Library Science
dc.relation.ispartof Plos One
dc.rights Acesso aberto
dc.title Plasma Cytokine Profile in Tropical Endomyocardial Fibrosis: Predominance of TNF-a, IL-4 and IL-10 en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution ProSangue Fdn
dc.contributor.institution Inst Investigat Immunol
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Sch Med, Inst Heart InCor, Immunol Lab, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Div Clin Immunol & Allergy, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Inst Heart InCor, Cardiomyopathy Unit, São Paulo, Brazil
dc.description.affiliation ProSangue Fdn, São Paulo, Brazil
dc.description.affiliation Inst Investigat Immunol, INCT, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, Div Immunol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, Div Immunol, São Paulo, Brazil
dc.identifier.file WOS000343730400039.pdf
dc.identifier.doi 10.1371/journal.pone.0108984
dc.description.source Web of Science
dc.identifier.wos WOS:000343730400039



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