Autor |
Miranda, Maisa F.
![]() Hamani, Clement ![]() ![]() Almeida, Antonio-Carlos G. de ![]() Amorim, Beatriz Oliveira ![]() ![]() Macedo, Carlos Eduardo ![]() ![]() Fernandes, Maria Jose da Silva ![]() ![]() Nobrega, Jose N. ![]() Aarao, Mayra C. ![]() Madureira, Ana Paula ![]() Rodrigues, Antonio M. ![]() Andersen, Monica Levy ![]() ![]() Tufik, Sergio ![]() ![]() Mello, Luiz Eugenio Araujo de Moraes ![]() Covolan, Luciene ![]() ![]() |
Instituição | Univ Fed Sao Joao del Rei Universidade Federal de São Paulo (UNIFESP) Ctr Addict & Mental Hlth Univ Toronto |
Resumo | Despite the effectiveness of anterior thalamic nucleus (AN) deep brain stimulation (DBS) for the treatment of epilepsy, mechanisms responsible for the antiepileptic effects of this therapy remain elusive. As adenosine modulates neuronal excitability and seizure activity in animal models, we hypothesized that this nucleoside could be one of the substrates involved in the effects of AN DBS. We applied 5 days of stimulation to rats rendered chronically epileptic by pilocarpine injections and recorded epileptiforrn activity in hippocampal slices. We found that slices from animals given DBS had reduced hippocampal excitability and were less susceptible to develop ictal activity. in live animals, AN DBS significantly increased adenosine levels in the hippocampus as measured by microdialysis. the reduced excitability of DBS in vitro was completely abolished in animals pre-treated with A1 receptor antagonists and was strongly potentiated by A1 receptor agonists. We conclude that some of the antiepileptic effects of DBS may be mediated by adenosine. |
Assunto |
deep brain stimulation
epilepsy thalamus anterior nucleus seizures adenosine |
Idioma | Inglês |
Financiador |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) AFIP (Associacao Fundo de Incentivo a Pesquisa) |
Número do financiamento |
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Data | 2014-10-02 |
Publicado em | Frontiers in Cellular Neuroscience. Lausanne: Frontiers Research Foundation, v. 8, 6 p., 2014. |
ISSN | 1662-5102 (Sherpa/Romeo, fator de impacto) |
Editor | Frontiers Research Foundation |
Extensão | 6 |
Fonte |
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Direito de acesso | Acesso aberto ![]() |
Tipo | Artigo |
Web of Science | WOS:000344523900001 |
URI | http://repositorio.unifesp.br/handle/11600/38319 |
Nome:
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