Role of adenosine in the antiepileptic effects of deep brain stimulation

Role of adenosine in the antiepileptic effects of deep brain stimulation

Autor Miranda, Maisa F. Google Scholar
Hamani, Clement Autor UNIFESP Google Scholar
Almeida, Antonio-Carlos G. de Google Scholar
Amorim, Beatriz Oliveira Autor UNIFESP Google Scholar
Macedo, Carlos Eduardo Autor UNIFESP Google Scholar
Fernandes, Maria Jose da Silva Autor UNIFESP Google Scholar
Nobrega, Jose N. Google Scholar
Aarao, Mayra C. Google Scholar
Madureira, Ana Paula Google Scholar
Rodrigues, Antonio M. Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Luiz Eugenio Araujo de Moraes Google Scholar
Covolan, Luciene Autor UNIFESP Google Scholar
Instituição Univ Fed Sao Joao del Rei
Universidade Federal de São Paulo (UNIFESP)
Ctr Addict & Mental Hlth
Univ Toronto
Resumo Despite the effectiveness of anterior thalamic nucleus (AN) deep brain stimulation (DBS) for the treatment of epilepsy, mechanisms responsible for the antiepileptic effects of this therapy remain elusive. As adenosine modulates neuronal excitability and seizure activity in animal models, we hypothesized that this nucleoside could be one of the substrates involved in the effects of AN DBS. We applied 5 days of stimulation to rats rendered chronically epileptic by pilocarpine injections and recorded epileptiforrn activity in hippocampal slices. We found that slices from animals given DBS had reduced hippocampal excitability and were less susceptible to develop ictal activity. in live animals, AN DBS significantly increased adenosine levels in the hippocampus as measured by microdialysis. the reduced excitability of DBS in vitro was completely abolished in animals pre-treated with A1 receptor antagonists and was strongly potentiated by A1 receptor agonists. We conclude that some of the antiepileptic effects of DBS may be mediated by adenosine.
Palavra-chave deep brain stimulation
epilepsy
thalamus
anterior nucleus
seizures
adenosine
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
AFIP (Associacao Fundo de Incentivo a Pesquisa)
Número do financiamento FAPESP: 2011150680-2
FAPESP: 50950-2
Data de publicação 2014-10-02
Publicado em Frontiers in Cellular Neuroscience. Lausanne: Frontiers Research Foundation, v. 8, 6 p., 2014.
ISSN 1662-5102 (Sherpa/Romeo, fator de impacto)
Publicador Frontiers Research Foundation
Extensão 6
Fonte http://dx.doi.org/10.3389/fncel.2014.00312
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000344523900001
Endereço permanente http://repositorio.unifesp.br/handle/11600/38319

Exibir registro completo




Arquivo

Nome: WOS000344523900001.pdf
Tamanho: 703.4KB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta