Children with Chronic Renal Disease Undergoing Dialysis or Conservative Treatment-Differences in Structural and Functional Echocardiographic Parameters

Children with Chronic Renal Disease Undergoing Dialysis or Conservative Treatment-Differences in Structural and Functional Echocardiographic Parameters

Author Scavarda, Valeska Tavares Autor UNIFESP Google Scholar
Pinheiro, Aurelio Carvalho Autor UNIFESP Google Scholar
Costa, Symone Damasceno Autor UNIFESP Google Scholar
Andrade, Zelia Maria de Autor UNIFESP Google Scholar
Abreu Carvalhaes, Joao Tomas de Autor UNIFESP Google Scholar
Campos, Orlando Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos Autor UNIFESP Google Scholar
Moises, Valdir Ambrosio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Cardiac disease frequently occurs in children with chronic kidney disease (CKD) undergoing dialysis (DI), but it is not well studied in patients undergoing conservative treatment (CT). the aim of our study was to use echocardiography to analyze and compare the cardiac involvement of children with CKD undergoing DI or CT. Methods: Seventy-one children with CKD were included; 41 undergoing DI and 30 undergoing CT. There were 33 controls. Measurements of arterial pressure and structural and functional echocardiographic variables were obtained; the children were followed up for 18 months. Tests of comparison and multiple regression were used; significant if P < 0.05. Results: Arterial hypertension (AH) was present in 37 of 71 (52%) children with CKD: 27 (65.8%) in DI and 10 (33.3%) in CT (X-2 = 8.7; P = 0.003). An abnormal left ventricular geometric pattern was present in 37/41 (90.3%) undergoing DI, 33 had left ventricular hypertrophy (LVH), and in 14/30 (46.7%) undergoing CT, 5 had LVH. Ejection fraction was normal in all groups; diastolic function alteration (DFA) occurred in 28/41 (68.3%) children on DI and in 10/30 (33.3%) on CT (X-2 = 9.2; P = 0.002). for children with CKD, DI (P = 0.002) and hypertension (P = 0.04) were associated with LVH; among those on DI, only AH was associated with LVH (P = 0.02). During the follow-up, 18 (43.9%) children undergoing DI had at least one cardiovascular event. Conclusion: Children with CKD undergoing CT had less cardiac involvement than those undergoing DI. LVH was associated with DI and AH in all children with CKD and with AH in those on DI.
Keywords children
echocardiography
chronic kidney disease
left ventricular hypertrophy
arterial hypertension
Language English
Date 2014-10-01
Published in Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques. Hoboken: Wiley-Blackwell, v. 31, n. 9, p. 1131-1137, 2014.
ISSN 0742-2822 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1131-1137
Origin http://dx.doi.org/10.1111/echo.12525
Access rights Closed access
Type Article
Web of Science ID WOS:000342827700021
URI http://repositorio.unifesp.br/handle/11600/38309

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