Oral microbial colonization in children with sickle cell anaemia under long-term prophylaxis with penicillin

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dc.contributor.author Matos, Bruno Mello de
dc.contributor.author Abreu Ribeiro, Zulene Eveline
dc.contributor.author Balducci, Ivan
dc.contributor.author Figueiredo, Maria Stella [UNIFESP]
dc.contributor.author Back-Brito, Graziella Nuernberg
dc.contributor.author Mota, Adolfo Jose da
dc.contributor.author Pellegrini Braga, Josefina Aparecida
dc.contributor.author Koga-Ito, Cristiane Yumi
dc.date.accessioned 2016-01-24T14:37:56Z
dc.date.available 2016-01-24T14:37:56Z
dc.date.issued 2014-10-01
dc.identifier http://dx.doi.org/10.1016/j.archoralbio.2014.05.014
dc.identifier.citation Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V., v. 59, n. 10, p. 1042-1047, 2014.
dc.identifier.issn 0003-9969
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38279
dc.description.abstract Background and objective: Sickle cell anaemia (SCA) is the most frequent haematological hereditary disease. Children with SCA are submitted to long-term prophylactic therapy with penicillin, but little is known about its impact on oral microflora. the aim of this study was to evaluate the oral microbial colonization of paediatric patients with SCA.Design: Forty children (4-11 yrs old) with SCA (genotype SS) under long-term prophylactic treatment with penicillin were included in the study. Age/gender-matched control group of healthy children was also included. Scores of dmft/DMFT (number of decayed (D), missing (M), or filled (F) teeth; dmft, for primary dentition; DMFT, for permanent dentition) were obtained and stimulated saliva was sampled. Salivary flow rate and buffering capacity were evaluated. Counts of microorganisms (mutans streptococci, lactobacilli and yeasts) were determined by plating method. Yeasts were identified by API 20C AUX and PCR.Results: Mean dmft/DMFT values were similar in the studied groups (SCA 2.13/1.60 and control 2.38/1.3). Although no significant differences between cariogenic microorganism counts were observed, significantly higher yeasts oral levels were observed in SCA group. Controls showed lower salivary buffering capacity. Candida albicans was the most frequently isolated species in both groups. Candida famata, Candida parapsilosis and Candida tropical is were also isolated from controls. Candida dubliniensis, Candida rugosa and Candida sphaerica were found only in SCA group.Conclusions: Based on the results, it could be concluded that paediatric patients with SCA showed significantly higher oral level of yeasts. Uncommon fungal species were found in SCA group. Similar caries prevalence and counts of lactobacilli and streptococci in relation to controls were observed. (C) 2014 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 1042-1047
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Archives of Oral Biology
dc.rights Acesso restrito
dc.subject Sickle cell anaemia en
dc.subject Children en
dc.subject Mouth en
dc.subject Caries en
dc.subject Microorganism en
dc.title Oral microbial colonization in children with sickle cell anaemia under long-term prophylaxis with penicillin en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Univ Estadual Paulista
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Fed Amazonas
dc.description.affiliation Univ Estadual Paulista, UNESP, Inst Sci & Technol, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliation Univ Fed Amazonas, Programa Multiinst Posgrad Biotecnol Manaus, Manaus, AM, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 07/58999-2
dc.identifier.doi 10.1016/j.archoralbio.2014.05.014
dc.description.source Web of Science
dc.identifier.wos WOS:000341481700005


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