Study of in vitro degradation of brushite cements scaffolds

Study of in vitro degradation of brushite cements scaffolds

Author Reno, Caroline de Oliveira Autor UNIFESP Google Scholar
Pereta, Nicholas C. Autor UNIFESP Google Scholar
Bertran, Celso A. Google Scholar
Motisuke, Mariana Autor UNIFESP Google Scholar
Sousa, Eliandra de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Abstract An interest path to fabricate supports for tissue engineering is to foam calcium phosphate cement's pastes leading to an increase on material's total porosity and interconnectivity which facilitates cells' adhesion, proliferation and differentiation. the aim of this work is to develop scaffolds of brushite cement and to evaluate its in vitro degradation rate. Macroporosity was obtained by foaming the liquid phase with different non-ionic surfactants (Tween 80 and Lutensol ON-110). the foam stability was achieved by adding chitosan. the scaffolds were immersed in Ringers(A (R)) solution during 7, 14, 21 and 28 days and samples' microstructure, weight loss, mechanical resistance and apparent porosity were evaluated. Both scaffolds presented interconnected macropores with sizes ranging from 100 to 360 A mu m and total porosities higher than 60 %. These properties could facilitate cell infiltration, bone growth and vascularization. the scaffolds obtained in this work should be considered as promising materials for application in bone tissue engineering.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2012/21198-0
FAPESP: 2010/00863-0
FAPESP: 2011/09240-9
Date 2014-10-01
Published in Journal of Materials Science-materials in Medicine. Dordrecht: Springer, v. 25, n. 10, p. 2297-2303, 2014.
ISSN 0957-4530 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 2297-2303
Access rights Closed access
Type Article
Web of Science ID WOS:000342421300009

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