The chemopreventive activity of apple against carcinogenesis: antioxidant activity and cell cycle control

The chemopreventive activity of apple against carcinogenesis: antioxidant activity and cell cycle control

Author Ribeiro, Flavia Andressa Pidone Autor UNIFESP Google Scholar
Gomes de Moura, Carolina Foot Autor UNIFESP Google Scholar
Aguiar, Odair Autor UNIFESP Google Scholar
Oliveira, Flavia de Autor UNIFESP Google Scholar
Spadari-Bratfisch, Regina Celia Autor UNIFESP Google Scholar
Oliveira, Nara Rejane Cruz de Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Apples and their derivatives are rich in phytochemicals, including flavonoids (catechins, flavonols, quercetin) and phenolic acids (quercetin glycosides, catechin, epicatechin, procyanidins), vitamins, and fibers, that confer an important antioxidant property. Chemoprevention is defined by the use of natural or synthetic agents to interfere with the progression, reverse, or inhibit carcinogenesis, thereby reducing the risk of developing clinically invasive disease. the aim of this article is to present data generated from the use of apples as a chemopreventive agent in carcinogenesis using in-vivo and in-vitro test systems. Apple and its bioactive compounds can exert chemopreventive properties as a result of antioxidant activity and cell cycle control. However, future focus of research on apple such as identifying the specific phytochemical responsible for the anticarcinogenic effect, timing of consumption, and adequate amount of apples to achieve the best preventive effect using human large randomized-controlled trials is needed. Furthermore, animal studies are also relevant for better understanding the role of this fruit in human health as well as modulation of degenerative diseases such as cancer. Therefore, this area warrants further investigation as a new way of thinking, which would apply not only to apples but also to other fruit used as promising therapeutic agents against human diseases. (c) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Keywords apple
cancer
chemoprevention
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2014-09-01
Published in European Journal of Cancer Prevention. Philadelphia: Lippincott Williams & Wilkins, v. 23, n. 5, p. 477-480, 2014.
ISSN 0959-8278 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 477-480
Origin http://dx.doi.org/10.1097/CEJ.0000000000000005
Access rights Closed access
Type Review
Web of Science ID WOS:000340559200019
URI http://repositorio.unifesp.br/handle/11600/38185

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