Unraveling snake venom complexity with 'omics' approaches: Challenges and perspectives

Unraveling snake venom complexity with 'omics' approaches: Challenges and perspectives

Author Zelanis, Andre Autor UNIFESP Google Scholar
Tashima, Alexandre Keiji Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The study of snake venom proteomes (venomics) has been experiencing a burst of reports, however the comprehensive knowledge of the dynamic range of proteins present within a single venom, the set of post-translational modifications (PTMs) as well as the lack of a comprehensive database related to venom proteins are among the main challenges in venomics research. the phenotypic plasticity in snake venom proteomes together with their inherent toxin proteoform diversity, points out to the use of integrative analysis in order to better understand their actual complexity. in this regard, such a systems venomics task should encompass the integration of data from transcriptomic and proteomic studies (specially the venom gland proteome), the identification of biological PTMs, and the estimation of artifactual proteomes and peptidomes generated by sample handling procedures. (C) 2014 Elsevier B.V. All rights reserved.
Keywords Snake venom
Venomics
Proteome
Peptidome
Systems venomics
Language English
Date 2014-09-01
Published in Toxicon. Oxford: Pergamon-Elsevier B.V., v. 87, n. 1, p. 131-134, 2014.
ISSN 0041-0101 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 131-134
Origin http://dx.doi.org/10.1016/j.toxicon.2014.05.011
Access rights Closed access
Type Letter
Web of Science ID WOS:000339145900016
URI http://repositorio.unifesp.br/handle/11600/38177

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