Antileishmanial activity evaluation of adunchalcone, a new prenylated dihydrochalcone from Piper aduncum L.

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dc.contributor.author Dal Picolo, Camilla R. [UNIFESP]
dc.contributor.author Bezerra, Mariana P. [UNIFESP]
dc.contributor.author Gomes, Kaio S. [UNIFESP]
dc.contributor.author Passero, Luiz Felipe D.
dc.contributor.author Laurenti, Marcia D.
dc.contributor.author Martins, Euder Glendes A.
dc.contributor.author Sartorelli, Patricia [UNIFESP]
dc.contributor.author Lago, Joao Henrique G. [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:48Z
dc.date.available 2016-01-24T14:37:48Z
dc.date.issued 2014-09-01
dc.identifier http://dx.doi.org/10.1016/j.fitote.2014.05.009
dc.identifier.citation Fitoterapia. Amsterdam: Elsevier B.V., v. 97, p. 28-33, 2014.
dc.identifier.issn 0367-326X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38164
dc.description.abstract Bioactivity-guided fractionation of EtOH extract from the leaves of Piper aduncum L. (Piperaceae) afforded a new dihydrochalcone, named adunchalcone. Its structure was elucidated on the basis of their spectroscopic data, primarily NMR and MS. Adunchalcone was evaluated against promastigote forms of Leishmania (L.) amazonensis, L. (V.) braziliensis, L. (V.) shawl, and L. (L.) chagasi and displayed 50% effective concentrations (EC50) of 11.03, 26.70, and 11.26 mu M, as well as selective indexes of 4.86, 2.01, 4.76 and 0.50, respectively. This compound was also tested against intracellular forms of L. (L.) amazonensis, displaying weak activity, in comparison to reference drug amphotericin B. However, despite reduced effect of adunchalcone against amastigotes of L. (L.) amazonensis, this work opens the perspective to use this particular molecule as a scaffold for the design of novel and selective drug candidates for neglected diseases, mainly leishmaniasis. (c) 2014 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 28-33
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Fitoterapia
dc.rights Acesso restrito
dc.subject Piper aduncum en
dc.subject Piperaceae en
dc.subject Antileishmanial en
dc.subject Dihydrochalcone en
dc.subject Adunchalcone en
dc.title Antileishmanial activity evaluation of adunchalcone, a new prenylated dihydrochalcone from Piper aduncum L. en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Med, Dept Patol, Lab Patol Molestias Infecciosas LIM50, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Inst Biociencias, Dept Bot, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: FAPESP - 2011/51739-0
dc.description.sponsorshipID CNPq: CNPq - 470853/2012-3
dc.identifier.doi 10.1016/j.fitote.2014.05.009
dc.description.source Web of Science
dc.identifier.wos WOS:000341346400004



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