Low-level laser therapy prevents degenerative morphological changes in an experimental model of anterior cruciate ligament transection in rats

Mostrar registro simples

dc.contributor.author Bublitz, Caroline [UNIFESP]
dc.contributor.author Medalha, Carla [UNIFESP]
dc.contributor.author Oliveira, Poliani [UNIFESP]
dc.contributor.author Assis, Livia [UNIFESP]
dc.contributor.author Milares, Luiz Paulo [UNIFESP]
dc.contributor.author Fernandes, Kelly Rossetti [UNIFESP]
dc.contributor.author Tim, Carla Roberta [UNIFESP]
dc.contributor.author Vasilceac, Fernando Augusto [UNIFESP]
dc.contributor.author Mattiello, Stela Marcia [UNIFESP]
dc.contributor.author Muniz Renno, Ana Claudia [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:47Z
dc.date.available 2016-01-24T14:37:47Z
dc.date.issued 2014-09-01
dc.identifier http://dx.doi.org/10.1007/s10103-014-1546-z
dc.identifier.citation Lasers in Medical Science. London: Springer London Ltd, v. 29, n. 5, p. 1669-1678, 2014.
dc.identifier.issn 0268-8921
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38140
dc.description.abstract The aim of this study was to analyze the effects of low-level laser therapy (LLLT) on the prevention of cartilage damage after the anterior cruciate ligament transection (ACLT) in knees of rats. Thirty male rats (Wistar) were distributed into three groups (n = 10 each): injured control group (CG); injured laser-treated group at 10 J/cm(2) (L10), and injured laser-treated group at 50 J/cm(2) (L50). Laser treatment started immediately after the surgery and it was performed for 15 sessions. An 808 nm laser, at 10 and 50 J/cm(2), was used. To evaluate the effects of LLLT, the qualitative and semi-quantitative histological, morphometric, and immunohistochemistry analysis were performed. Initial signs of tissue degradation were observed in CG. Interestingly, laser-treated animals presented a better tissue organization, especially at the fluence of 10 J/cm(2). Furthermore, laser phototherapy was able of modulating some of the aspects related to the degenerative process, such as the prevention of proteoglycans loss and the increase in cartilage area. However, LLLT was not able of modulating chondrocytes proliferation and the immunoexpression of markers related to inflammatory process (IL-1 and MMP-13). This study showed that 808 nm laser, at both fluences, prevented features related to the articular degenerative process in the knees of rats after ACLT. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 1669-1678
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Lasers in Medical Science
dc.rights Acesso restrito
dc.subject LLLT en
dc.subject Articular cartilage en
dc.subject Proteoglycan en
dc.subject Metalloproteinase 13 en
dc.subject Interleukin-1 en
dc.title Low-level laser therapy prevents degenerative morphological changes in an experimental model of anterior cruciate ligament transection in rats en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Biosci, BR-11050240 Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Physiotherapy, Sao Carlos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biosci, BR-11050240 Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Physiotherapy, Sao Carlos, SP, Brazil
dc.identifier.doi 10.1007/s10103-014-1546-z
dc.description.source Web of Science
dc.identifier.wos WOS:000341503500020



Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)

Mostrar registro simples