Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children

Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children

Autor Pugliese, Camila Autor UNIFESP Google Scholar
Patin, Rose Vega Autor UNIFESP Google Scholar
Palchetti, Cecilia Zanin Autor UNIFESP Google Scholar
Claudio, Cristiane Chiantelli Autor UNIFESP Google Scholar
Gouvêa, Aida de Fátima Thomé Barbosa Autor UNIFESP Google Scholar
Succi, Regina Célia de Menezes Autor UNIFESP Google Scholar
Amancio, Olga Maria Silverio Autor UNIFESP Google Scholar
Cozzolino, Silvia Maria Franciscato Google Scholar
Oliveira, Fernanda Luisa Ceragioli Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Objective: This study aims to assess the nutritional status of selenium, copper and zinc; and also the erythrocyte superoxide dismutase activity of HIV-infected children compared to a control group.Methods: A cross-sectional study was carried out with prepubertal HIV-infected children (n = 51) and their healthy siblings (n = 32). All biochemical measurements including plasma selenium, serum copper levels, serum and erythrocyte zinc levels and erythrocyte superoxide dismutase activity were evaluated according to dietary, clinical and biochemical parameters.Results: Compared to the control group, the HIV-infected children had lower z-score values for height-for-age (p = 0.0006), higher prevalence of stunting (11.8%) (p = 0.047), lower selenium levels (p = 0.0006) and higher copper levels (p = 0.019). No difference was found concerning superoxide dismutase activity (p > 0.05). the HIV-infected group presented a higher proportion (45.1%) of children with zinc intakes below the estimated average requirement (p = 0.014); however, no association with zinc biochemical parameters was found.Conclusion: HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress. (C) 2014 Elsevier Editora Ltda. All rights reserved.
Assunto Antioxidants
HIV and nutrition
Oxidative stress
Trace elements
Idioma Inglês
Data 2014-09-01
Publicado em Brazilian Journal of Infectious Diseases. Salvador: Contexto, v. 18, n. 5, p. 481-486, 2014.
ISSN 1413-8670 (Sherpa/Romeo, fator de impacto)
Editor Contexto
Extensão 481-486
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000346072300003
SciELO S1413-86702014000500481 (estatísticas na SciELO)

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