Morphometric hemispheric asymmetry of orbitofrontal cortex in women with borderline personality disorder: A multi-parameter approach

Morphometric hemispheric asymmetry of orbitofrontal cortex in women with borderline personality disorder: A multi-parameter approach

Author Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
Abdallah, Chadi Google Scholar
Sato, Joao Ricardo Autor UNIFESP Google Scholar
Araujo, Thabata Bueno de Autor UNIFESP Google Scholar
Lisondo, Claudio Mauricio Autor UNIFESP Google Scholar
Faria, Alvaro Ancona de Autor UNIFESP Google Scholar
Lin, Katia Autor UNIFESP Google Scholar
Silva, Ivaldo Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Ramalho da Silva, Julieta Freitas Autor UNIFESP Google Scholar
Coplan, Jeremy Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Yale Univ
Universidade Federal do ABC (UFABC)
Suny Downstate Med Ctr
Abstract Functional imaging studies have implicated the orbitofrontal cortex (OFC) in the pathophysiology of borderline personality disorder (BPD). To date, however, volume-based magnetic resonance imaging (MRI) studies have yielded mixed results. We used a surface-based processing approach that allowed us to measure five morphometric cortical features of the OFC, including volumetric (cortical thickness and surface area) and geometric (mean curvature, depth of sulcus, and metric distortion three indicators of cortical folding) parameters. Participants comprised 25 female BPD patients with no other current psychiatric comorbidity and 25 age- and gender-matched healthy controls who received structural MRI scans. Images were processed using the Freesurfer package. All BPD patients had a history of comorbid psychiatric disorder(s) and were currently on medications. Compared with controls, the BPD group showed reduced cortical thickness, surface area, mean curvature, depth of sulcus, and metric distortion in the right medial OFC. in the left medial OFC, the BPD group had reduced cortical thickness and mean curvature, but increased metric distortion. This study confirmed the utility of surface-based analysis in the study of BPD cortical structures. in addition, we observed extensive structural abnormalities in the medial OFC of female subjects with BPD, findings that were most pronounced in the right OFC, with preliminary data suggesting hemispheric asymmetry. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Keywords Magnetic resonance imaging
Cortical thickness
Multimodal analysis
Language English
Date 2014-08-30
Published in Psychiatry Research-neuroimaging. Clare: Elsevier B.V., v. 223, n. 2, p. 61-66, 2014.
ISSN 0925-4927 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 61-66
Origin http://dx.doi.org/10.1016/j.pscychresns.2014.05.001
Access rights Closed access
Type Article
Web of Science ID WOS:000340014300002
URI http://repositorio.unifesp.br/handle/11600/38111

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