Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system

Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system

Author Rial, Daniel Google Scholar
Pamplona, Fabricio A. Google Scholar
Moreira, Eduardo L. G. Google Scholar
Moreira, Karin M. Autor UNIFESP Google Scholar
Hipolide, Debora Autor UNIFESP Google Scholar
Rodrigues, Diana I. Google Scholar
Dombrowski, Patricia A. Google Scholar
Da Cunha, Claudio Google Scholar
Agostinho, Paula Google Scholar
Takahashi, Reinaldo N. Google Scholar
Walz, Roger Google Scholar
Cunha, Rodrigo A. Google Scholar
Prediger, Rui D. Google Scholar
Institution Universidade Federal de Santa Catarina (UFSC)
Rua Larga Univ Coimbra
DOr Inst Res & Educ
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Paraná (UFPR)
Univ Coimbra
Hosp Governador Celso Ramos
Abstract Cellular prion protein (PrPC) is widely expressed in the brain. Although the precise role of PrPC remains uncertain, it has been proposed to be a pivotal modulator of neuroplasticity events by regulating the glutamatergic and serotonergic systems. Here we report the existence of neurochemical and functional interactions between PrPC and the dopaminergic system. PrPC was found to co-localize with dopaminergic neurons and in dopaminergic synapses in the striatum. Furthermore, the genetic deletion of PrPC down-regulated dopamine D-1 receptors and DARPP-32 density in the striatum and decreased dopamine levels in the prefrontal cortex of mice. This indicates that PrPC affects the homeostasis of the dopaminergic system by interfering differently in different brain areas with dopamine synthesis, content, receptor density and signaling pathways. This interaction between PrPC and the dopaminergic system prompts the hypotheses that the dopaminergic system may be implicated in some pathological features of prion-related diseases and, conversely, that PrPC may play a role in dopamine-associated brain disorders.
Keywords behavior
cellular prion protein
dopamine
dopamine receptor
striatum
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Programa de Apoio aos Nucleos de Excelencia (PRONEX- NENASC Project)
Fundacao de Apoio a Pesquisa do Estado de Santa Catarina (FAPESC)
Fundacao para a Ciencia e Tecnologia
Grant number Fundacao para a Ciencia e Tecnologia: PTDC/SAU-NMC/114810/2009
Date 2014-08-01
Published in European Journal of Neuroscience. Hoboken: Wiley-Blackwell, v. 40, n. 3, p. 2479-2486, 2014.
ISSN 0953-816X (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 2479-2486
Origin http://dx.doi.org/10.1111/ejn.12600
Access rights Closed access
Type Article
Web of Science ID WOS:000340502500002
URI http://repositorio.unifesp.br/handle/11600/38065

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