Liquid nitrogen for the treatment of actinic keratosis: A longitudinal assessment

Liquid nitrogen for the treatment of actinic keratosis: A longitudinal assessment

Author Ianhez, Mayra Google Scholar
Miot, Hello Amante Google Scholar
Bagatin, Edileia Autor UNIFESP Google Scholar
Institution Universidade Federal de Goiás (UFG)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Cryosurgery with liquid nitrogen is one of the most used treatments for actinic keratosis. We aimed to study the effectiveness of two consecutive sessions of cryosurgery for actinic keratosis and investigate factors associated with its therapeutic success. Hence, we conducted a longitudinal study including 92 patients of both sexes, aged 50-75 years with 5-50 actinic keratosis on the face and forearms, who underwent cryosurgery and treatment with sunscreen SPF 30, at baseline and after 120 days. the lesions were counted in duplicate by the same examiner before the start of treatment and after 120 (N = 92) and 300 days (N = 33), represented by their medians and quartiles and compared using the generalized linear mixed effects model (negative binomial). Treatment behavior was investigated in relation to sex, age, education, skin type, smoking, sun exposure at work and the use of aspirin, anti-inflammatory and angiotensin-converting enzyme inhibitors. There was a significant reduction in the actinic keratosis count on the face and forearms (p < 0.05). Our results confirmed the effectiveness of cryosurgery for actinic keratosis, with a 57% reduction in the number, and size of the lesions. Higher education levels (p = 0.02) and less sun exposure at work (p = 0.02) independently promoted a significant reduction in the actinic keratosis count. Different population groups showed characteristic responses to the treatment, which may be explained by the degree of adherence to the use of photoprotection. in two sessions, cryosurgery with liquid nitrogen reduced the actinic keratosis count. (C) 2014 Elsevier Inc. All rights reserved.
Keywords Cryosurgery
Actinic keratosis
Carcinogenesis
Prevention and control
Skin neoplasm
Treatment outcome
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number 476243.2011/4
Date 2014-08-01
Published in Cryobiology. San Diego: Academic Press Inc Elsevier Science, v. 69, n. 1, p. 140-143, 2014.
ISSN 0011-2240 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 140-143
Origin http://dx.doi.org/10.1016/j.cryobiol.2014.06.006
Access rights Closed access
Type Article
Web of Science ID WOS:000340691700021
URI http://repositorio.unifesp.br/handle/11600/38046

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