Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide

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dc.contributor.author Pidone Ribeiro, Flavia Andressa [UNIFESP]
dc.contributor.author Gomes de Moura, Carolina Foot [UNIFESP]
dc.contributor.author Boiago Gollucke, Andrea Pitelli
dc.contributor.author Ferreira, Monica Siqueira
dc.contributor.author Catharino, Rodrigo Ramos
dc.contributor.author Aguiar, Odair [UNIFESP]
dc.contributor.author Spadari, Regina Celia [UNIFESP]
dc.contributor.author Barbisan, Luis Fernando
dc.contributor.author Ribeiro, Daniel Araki [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:39Z
dc.date.available 2016-01-24T14:37:39Z
dc.date.issued 2014-08-01
dc.identifier http://dx.doi.org/10.1016/j.archoralbio.2014.04.013
dc.identifier.citation Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V., v. 59, n. 8, p. 815-821, 2014.
dc.identifier.issn 0003-9969
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38040
dc.description.abstract Objective: the aim of this study was to evaluate the chemopreventive activity of an apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide (4NQO).Methods: A total of 30 male Wistar rats were distributed into five groups as follows (n = 6 per group): Group 1, negative control group (non-treated group); Group 2, received 4NQO during 8 weeks in drinking water and treated with apple extract at 1% by gavage between the first and fourth weeks daily (initiation phase); Group 3, received 4NQO for 8 weeks in drinking water and treated with apple extract by gavage at 1% between the fifth and eighth weeks daily (promotion phase); Group 4, received apple extract at 1% by gavage for 8 consecutive weeks only; and Group 5, received 4NQO for 8 weeks in drinking water daily.Results: Histopathological analysis revealed decreased hyperplasic lesions in Group 2 when compared with Group 5. Likewise, decreased dysplastic lesions in Group 3 were observed when compared with Group 5. in Groups 2 and 3, decreased COX-2 and TNF-alpha gene expressions were observed when compared with Group 5. Cytochrome c and caspase 3 levels increased in Groups 2 and 3 when compared with Group 5.Conclusion: in conclusion, our results demonstrate that apple extract suppresses rat tongue carcinogenesis as a result of anti-inflammatory activity and apoptosis through the intrinsic mitochondrial pathway. (C) 2014 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 815-821
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Archives of Oral Biology
dc.rights Acesso restrito
dc.subject Apple extract en
dc.subject 4-Nitroquinoline-1-oxide en
dc.subject Oral cancer en
dc.subject Inflammation en
dc.subject Apoptosis en
dc.title Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Catholic Santos Univ
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Dept Pathol, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Catholic Santos Univ, Hexalab, Santos, SP, Brazil
dc.description.affiliation Univ Estadual Campinas, Med & Expt Surg Nucleus, INNOVARE Biomarkers Lab, Campinas, SP, Brazil
dc.description.affiliation Univ Estadual Paulista, Inst Biosci, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Dept Pathol, BR-11060001 Santos, SP, Brazil
dc.identifier.doi 10.1016/j.archoralbio.2014.04.013
dc.description.source Web of Science
dc.identifier.wos WOS:000338822300007



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