Fibromyalgia and Sleep in Animal Models: A Current Overview and Future Directions

Fibromyalgia and Sleep in Animal Models: A Current Overview and Future Directions

Author Frange, Cristina Autor UNIFESP Google Scholar
Hirotsu, Camila Autor UNIFESP Google Scholar
Hachul, Helena Autor UNIFESP Google Scholar
Araujo, Paula Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Sleep disorders are highly prevalent in patients with fibromyalgia (FM). Many of the daytime symptoms, such as chronic pain and fatigue, may be related to the non-restorative sleep patterns associated with the disease. Pain influences the sleep process and sleep disturbances decrease the pain threshold in a reciprocal framework. Thus, understanding the link between sleep and FM has become an important research topic in basic science. Therefore, in the current review we connect these topics and provide some insights into the cyclic relationship between sleep and pain, which has been addressed mainly in animal models. Additionally, we highlight the urgent need for sleep studies in FM animal models, which might improve the knowledge base and accelerate advances in this field.
Keywords Sleep
Fibromyalgia
Animal models
Chronic pain
Allodynia
Hyperalgesia
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 10/50130-0
Date 2014-08-01
Published in Current Pain and Headache Reports. New York: Springer, v. 18, n. 8, 10 p., 2014.
ISSN 1531-3433 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 10
Origin http://dx.doi.org/10.1007/s11916-014-0434-3
Access rights Closed access
Type Review
Web of Science ID WOS:000340092100001
URI http://repositorio.unifesp.br/handle/11600/38038

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