Comparative Study of Conjunctival Limbal Transplantation Not Associated With the Use of Amniotic Membrane Transplantation for Treatment of Total Limbal Deficiency Secondary to Chemical Injury

Comparative Study of Conjunctival Limbal Transplantation Not Associated With the Use of Amniotic Membrane Transplantation for Treatment of Total Limbal Deficiency Secondary to Chemical Injury

Author Barreiro, Telma P. Autor UNIFESP Google Scholar
Santos, Myrna S. Autor UNIFESP Google Scholar
Vieira, Ana C. Autor UNIFESP Google Scholar
Barros, Jeison de Nadai Autor UNIFESP Google Scholar
Hazarbassanov, Rossen M. Autor UNIFESP Google Scholar
Gomes, José Álvaro Pereira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose:The aim of this study was to compare the outcome of conjunctival limbal transplantation with and without the use of amniotic membrane (AM) transplantation for the treatment of limbal deficiency after chemical burns to the eyes.Methods:This is a retrospective, comparative, interventional case series that included 34 eyes (34 patients) with total limbal deficiency after chemical burns, who were submitted to conjunctival limbal transplantation. Two groups were formed: group 1 (15 eyes) limbal transplantation associated with AM transplantation and group 2 (19 eyes) only limbal transplantation. Success and failure rates, epithelialization time, and visual acuity were compared between the 2 groups.Results:The mean follow-up period was 19.71 5.6 months in group 1 and 18.26 +/- 7.78 months in group 2. the proportion of conjunctival limbal autograft and living-related conjunctival limbal allograft was similar in both groups (P = 0.914). Time until complete epithelialization of the corneal surface was significantly longer in group 1 (P = 0.007). Graft survival was similar in both groups (P = 0.581). Failure rate was also similar in both groups (P = 0.232). the most common cause of failure was transplanted stem cell depletion in group 1 (20% of cases) and rejection in group 2 (10.5%). the visual acuity improved postoperatively in 12 eyes (80%) in group 1 and 16 (84.2%) in group 2 (P = 0.430).Conclusions:Results with the use of AM associated with conjunctival limbal transplantation in ocular surface reconstruction were similar to those obtained with limbal transplantation alone. Both techniques were found to be satisfactory for ocular surface reconstruction in patients with total limbal deficiency after chemical burns.
Keywords conjunctival limbal transplantation
amniotic membrane transplantation
limbal deficiency
Language English
Date 2014-07-01
Published in Cornea. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 7, p. 716-720, 2014.
ISSN 0277-3740 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 716-720
Origin http://dx.doi.org/10.1097/ICO.0000000000000139
Access rights Closed access
Type Article
Web of Science ID WOS:000337748400014
URI http://repositorio.unifesp.br/handle/11600/37966

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