The relationship between nutritional status, vitamin A and zinc levels and oxidative stress in patients with ataxia-telangiectasia

The relationship between nutritional status, vitamin A and zinc levels and oxidative stress in patients with ataxia-telangiectasia

Author Silva, R. da Autor UNIFESP Google Scholar
Santos-Valente, E. C. dos Autor UNIFESP Google Scholar
Scomparini, F. Burim Autor UNIFESP Google Scholar
Sarni, Roseli Oselka Saccardo Autor UNIFESP Google Scholar
Costa-Carvalho, B. T. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Alfenas
ABC Univ
Abstract Background: Ataxia-telangiectasia (A-T) is a rare and degenerative disease that leads to varying degrees of immunodeficiency, oxidative stress, and malnutrition. Vitamin A and zinc are essential for immune function and antioxidant defence.Objective: To compare levels of retinol, beta carotene, and zinc in patients with ataxia-telangiectasia and healthy controls.Methods: We performed a cross-sectional study with 14 AT patients and 14 healthy controls matched for age and gender. All participants underwent a nutritional and laboratory evaluation comprising concentrations of retinol, beta carotene, serum and erythrocyte zinc, malondialdehyde (MDA), T lymphocyte numbers (CD4(+) and CD8(+)) and immunoglobulin (IgA).Results: the AT patients showed high rates of malnutrition with reduced lean body mass when compared to the control group. However, the concentrations of MDA, retinol, beta carotene, and serum and erythrocyte zinc in AT patients were similar to those of the control group. the retinol levels presented a negative correlation with MDA and positive correlation with IgA serum level.Conclusions: the AT patients assessed showed no change in nutritional status for vitamin A and zinc; however, they presented severe impairment in overall nutritional status observed and correlation between retinol with MDA and IgA. (C) 2012 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.
Keywords Ataxia-telangiectasia
Oxidative stress
Retinol
Zinc
Nutritional status
Immune system
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 08705-5/2008
Date 2014-07-01
Published in Allergologia Et Immunopathologia. Barcelona: Elsevier Doyma Sl, v. 42, n. 4, p. 329-335, 2014.
ISSN 0301-0546 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 329-335
Origin http://dx.doi.org/10.1016/j.aller.2013.02.013
Access rights Closed access
Type Article
Web of Science ID WOS:000339227000011
URI http://repositorio.unifesp.br/handle/11600/37931

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