The influence of nutritional status and disease on adiponectin and TNF-alpha levels in colorectal cancer patients

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dc.contributor.author Vicente, Mariana Abe [UNIFESP]
dc.contributor.author Silva, Tiago Donizetti [UNIFESP]
dc.contributor.author Barao, Katia [UNIFESP]
dc.contributor.author Felipe, Aledson Vitor [UNIFESP]
dc.contributor.author Missae, Lila Oyama
dc.contributor.author Forones, Nora Manoukian [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:30Z
dc.date.available 2016-01-24T14:37:30Z
dc.date.issued 2014-07-01
dc.identifier http://dx.doi.org/10.3305/nh.2014.30.1.7132
dc.identifier.citation Nutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 30, n. 1, p. 140-146, 2014.
dc.identifier.issn 0212-1611
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37908
dc.description.abstract Background: the aim of this study was to evaluate the association between adiponectin and tumor necrosis factor-a (TNF-alpha) serum levels in colorectal cancer (CRC) patients and compare these levels to clinical stage and nutritional status.Methods: A total of 79 patients were enrolled in the study (39 with CRC and 40 in the control). Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), and phase angle (PhA). Adiponectin and TNF-alpha serum concentrations were determined using an enzyme-linked immunosorbent assay.Results: Serum adiponectin levels were higher among CRC patients (p = 0.001). TNF-alpha serum levels were not significantly different between the groups, but patients with stage III or IV CRC had higher levels of TNF-alpha than those with lower stage disease (p = 0.037). the three tools used for the assessment of nutritional status (BMI, PhA, and PG-SGA) demonstrated that patients with a more severe nutritional deficit had higher adipocytokine levels, although these differences were significant only to TNF-alpha, when distributed PhA in tertiles.Conclusions: Adiponectin levels were higher among CRC patients. Although TNF-alpha serum levels from CRC patients did not differ significantly to the control group, CRC patients with stage III or IV had higher levels compared to those with stage I and II tumors. Nutritional status, as determined by BMI, PhA, and PG-SGA, demonstrated that patients with a greatest nutritional deficit, had higher levels of adipocytokines; however, these differences were significant only for TNF-alpha, when distributed PhA in tertiles. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 140-146
dc.language.iso eng
dc.publisher Aula Medica Ediciones
dc.relation.ispartof Nutricion Hospitalaria
dc.rights Acesso aberto
dc.subject Adipocytokines en
dc.subject Colorectal Cancer en
dc.subject Nutrition Assessment en
dc.title The influence of nutritional status and disease on adiponectin and TNF-alpha levels in colorectal cancer patients en
dc.title.alternative Influencia del estado nutritivo y la enfermedad sobre las concentraciones de adiponectina y TNF-α en pacientes con cáncer colorrectal es
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Dept Physiol
dc.description.affiliation Escola Paulista Med, Dept Med, Div Gastroenterol, Oncol Grp, BR-04023 São Paulo, Brazil
dc.description.affiliation Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifesp Escola Paulista Med, Dept Med, Div Gastroenterol, Oncol Grp, BR-04023 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 10/19191-2
dc.identifier.file WOS000340864700018.pdf
dc.identifier.doi 10.3305/nh.2014.30.1.7132
dc.description.source Web of Science
dc.identifier.wos WOS:000340864700018



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