The influence of nutritional status and disease on adiponectin and TNF-alpha levels in colorectal cancer patients

The influence of nutritional status and disease on adiponectin and TNF-alpha levels in colorectal cancer patients

Alternative title Influencia del estado nutritivo y la enfermedad sobre las concentraciones de adiponectina y TNF-α en pacientes con cáncer colorrectal
Author Vicente, Mariana Abe Autor UNIFESP Google Scholar
Silva, Tiago Donizetti Autor UNIFESP Google Scholar
Barao, Katia Autor UNIFESP Google Scholar
Felipe, Aledson Vitor Autor UNIFESP Google Scholar
Missae, Lila Oyama Google Scholar
Forones, Nora Manoukian Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Dept Physiol
Abstract Background: the aim of this study was to evaluate the association between adiponectin and tumor necrosis factor-a (TNF-alpha) serum levels in colorectal cancer (CRC) patients and compare these levels to clinical stage and nutritional status.Methods: A total of 79 patients were enrolled in the study (39 with CRC and 40 in the control). Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), and phase angle (PhA). Adiponectin and TNF-alpha serum concentrations were determined using an enzyme-linked immunosorbent assay.Results: Serum adiponectin levels were higher among CRC patients (p = 0.001). TNF-alpha serum levels were not significantly different between the groups, but patients with stage III or IV CRC had higher levels of TNF-alpha than those with lower stage disease (p = 0.037). the three tools used for the assessment of nutritional status (BMI, PhA, and PG-SGA) demonstrated that patients with a more severe nutritional deficit had higher adipocytokine levels, although these differences were significant only to TNF-alpha, when distributed PhA in tertiles.Conclusions: Adiponectin levels were higher among CRC patients. Although TNF-alpha serum levels from CRC patients did not differ significantly to the control group, CRC patients with stage III or IV had higher levels compared to those with stage I and II tumors. Nutritional status, as determined by BMI, PhA, and PG-SGA, demonstrated that patients with a greatest nutritional deficit, had higher levels of adipocytokines; however, these differences were significant only for TNF-alpha, when distributed PhA in tertiles.
Keywords Adipocytokines
Colorectal Cancer
Nutrition Assessment
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 10/19191-2
Date 2014-07-01
Published in Nutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 30, n. 1, p. 140-146, 2014.
ISSN 0212-1611 (Sherpa/Romeo, impact factor)
Publisher Aula Medica Ediciones
Extent 140-146
Origin http://dx.doi.org/10.3305/nh.2014.30.1.7132
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000340864700018
URI http://repositorio.unifesp.br/handle/11600/37908

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