Revealing the role of the autonomic nervous system in the development and maintenance of Goldblatt hypertension in rats

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dc.contributor.author Oliveira-Sales, Elizabeth Barbosa de [UNIFESP]
dc.contributor.author Toward, Marie Ann
dc.contributor.author Campos, Ruy Ribeiro [UNIFESP]
dc.contributor.author Julian Francis Richmond
dc.date.accessioned 2016-01-24T14:37:28Z
dc.date.available 2016-01-24T14:37:28Z
dc.date.issued 2014-07-01
dc.identifier http://dx.doi.org/10.1016/j.autneu.2014.02.001
dc.identifier.citation Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 183, p. 23-29, 2014.
dc.identifier.issn 1566-0702
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37883
dc.description.abstract Despite extensive use of the renovascular/Goldblatt model of hypertension-2K-1C, and the use of renal denervation to treat drug resistant hypertensive patients, autonomic mechanisms that underpin the maintenance of this hypertension are important yet remain unclear. Our aim was to analyse cardiovascular autonomic function by power spectral density analysis of both arterial pressure and pulse interval measured continuously by radio telemetry for 6 weeks after renal artery clipping. Mean arterial pressure increased from 106 +/- 5 to 185 +/- 2 mm Hg during 5 weeks post clipping when it stabilized. A tachycardia developed during the 4th week, which plateaued between weeks 5 and 6. the gain of the cardiac vagal baroreflex decreased immediately after clipping and continued to do so until the 5th week when it plateaued (from -2.4 +/- 0.09 to -0.8 +/- 0.04 bpm/mm Hg; P < 0.05). A similar time course of changes in the high frequency power spectral density of the pulse interval was observed (decrease from 13.4 +/- 0.6 to 8.3 +/- 0.01 ms(2); P < 0.05). There was an increase in both the very low frequency and low frequency components of systolic blood pressure that occurred 3 and 4 weeks after clipping, respectively. Thus, we show for the first time the temporal profile of autonomic mechanisms underpinning the initiation, development and maintenance of renovascular hypertension including: an immediate depression of cardiac baroreflex gain followed by a delayed cardiac sympathetic predominance; elevated sympathetic vasomotor drive occurring after the initiation of the hypertension but coinciding during its mid-development and maintenance. (C) 2014 the Authors. Published by Elsevier B.V. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship British Heart Foundation
dc.description.sponsorship NIH
dc.format.extent 23-29
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Autonomic Neuroscience-basic & Clinical
dc.rights Acesso aberto
dc.subject Autonomic nervous system en
dc.subject Spectral analysis en
dc.subject 2K-1C hypertension en
dc.title Revealing the role of the autonomic nervous system in the development and maintenance of Goldblatt hypertension in rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Univ Bristol
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Bristol, Sch Physiol & Pharmacol, Bristol BS8 1TD, Avon, England
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.identifier.file WOS000339137800005.pdf
dc.identifier.doi 10.1016/j.autneu.2014.02.001
dc.description.source Web of Science
dc.identifier.wos WOS:000339137800005



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