Revealing the role of the autonomic nervous system in the development and maintenance of Goldblatt hypertension in rats

Revealing the role of the autonomic nervous system in the development and maintenance of Goldblatt hypertension in rats

Author Oliveira-Sales, Elizabeth Barbosa de Autor UNIFESP Google Scholar
Toward, Marie Ann Google Scholar
Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Julian Francis Richmond Google Scholar
Institution Univ Bristol
Universidade Federal de São Paulo (UNIFESP)
Abstract Despite extensive use of the renovascular/Goldblatt model of hypertension-2K-1C, and the use of renal denervation to treat drug resistant hypertensive patients, autonomic mechanisms that underpin the maintenance of this hypertension are important yet remain unclear. Our aim was to analyse cardiovascular autonomic function by power spectral density analysis of both arterial pressure and pulse interval measured continuously by radio telemetry for 6 weeks after renal artery clipping. Mean arterial pressure increased from 106 +/- 5 to 185 +/- 2 mm Hg during 5 weeks post clipping when it stabilized. A tachycardia developed during the 4th week, which plateaued between weeks 5 and 6. the gain of the cardiac vagal baroreflex decreased immediately after clipping and continued to do so until the 5th week when it plateaued (from -2.4 +/- 0.09 to -0.8 +/- 0.04 bpm/mm Hg; P < 0.05). A similar time course of changes in the high frequency power spectral density of the pulse interval was observed (decrease from 13.4 +/- 0.6 to 8.3 +/- 0.01 ms(2); P < 0.05). There was an increase in both the very low frequency and low frequency components of systolic blood pressure that occurred 3 and 4 weeks after clipping, respectively. Thus, we show for the first time the temporal profile of autonomic mechanisms underpinning the initiation, development and maintenance of renovascular hypertension including: an immediate depression of cardiac baroreflex gain followed by a delayed cardiac sympathetic predominance; elevated sympathetic vasomotor drive occurring after the initiation of the hypertension but coinciding during its mid-development and maintenance. (C) 2014 the Authors. Published by Elsevier B.V.
Keywords Autonomic nervous system
Spectral analysis
2K-1C hypertension
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
British Heart Foundation
Date 2014-07-01
Published in Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 183, p. 23-29, 2014.
ISSN 1566-0702 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 23-29
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000339137800005

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