Diffusion tensor imaging of the cervical spinal cord of patients with Neuromyelitis Optica

Diffusion tensor imaging of the cervical spinal cord of patients with Neuromyelitis Optica

Author Rivero, Rene L. M. Autor UNIFESP Google Scholar
Oliveira, Enedina M. L. Autor UNIFESP Google Scholar
Bichuetti, Denis B. Autor UNIFESP Google Scholar
Gabbai, Alberto Alain Autor UNIFESP Google Scholar
Nogueira, Roberto G. Autor UNIFESP Google Scholar
Abdala, Nitamar Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Previous studies have demonstrated a correlation between Expanded Disability Status Scale (EDSS) and Diffusion Tensor Imaging (DTI) metrics, but the conclusions were based on evaluations of the entire cervical spinal cord.Objectives: the purpose of this study was to quantify the FA and MD values in the spinal cord of NMO patients, separating the lesion sites from the preserved sites, which has not been previously preformed. in addition, we attempted to identify a correlation with EDSS.Methods: DTI was performed in 11 NMO patients and 11 healthy individuals using a 1.5-T MRI scanner. We measured the FA and MD at ROIs positioned along the cervical spinal cord. the mean values of FA and MD at lesion, preserved and spinal cord sites were compared with those of a control group. We tested the correlations between the mean FA and MD with EDSS.Results: FA in NMO patients was significantly reduced in lesion sites (0.44 vs. 0.55, p = 0.0046), preserved sites (0.46 vs. 0.55, p = 0.0015), and all sites (0.45 vs 0.55, p = 0.0013) while MD increased only in lesion sites (1.03 x 10(-3) mm(2)/s vs. 0.90 x 10(-3) mm(2)/s, p = 0.009). the FA demonstrated the best correlation with EDSS (r = -0.7603, p = 0.0086), particularly at lesion sites.Conclusions: the results reinforce the importance of the FA index and confirm the hypothesis that NMO is a diffuse disease. (C) 2014 Elsevier Inc. All rights reserved.
Keywords Neuromyelitis optica
Diffusion tensor imaging
Spinal cord
Disability evaluation
Language English
Sponsor TEVA Pharmaceutical (Brazilian branch)
Date 2014-06-01
Published in Magnetic Resonance Imaging. New York: Elsevier B.V., v. 32, n. 5, p. 457-463, 2014.
ISSN 0730-725X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 457-463
Origin http://dx.doi.org/10.1016/j.mri.2014.01.023
Access rights Closed access
Type Article
Web of Science ID WOS:000335422800008
URI http://repositorio.unifesp.br/handle/11600/37835

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