ABANDON the MOUSE RESEARCH SHIP? NOT JUST YET!

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dc.contributor.author Osuchowski, Marcin F.
dc.contributor.author Remick, Daniel G.
dc.contributor.author Lederer, James A.
dc.contributor.author Lang, Charles H.
dc.contributor.author Aasen, Ansgar O.
dc.contributor.author Aibiki, Mayuki
dc.contributor.author Azevedo, Luciano C.
dc.contributor.author Bahrami, Soheyl
dc.contributor.author Boros, Mihaly
dc.contributor.author Cooney, Robert
dc.contributor.author Cuzzocrea, Salvatore
dc.contributor.author Jiang, Yong
dc.contributor.author Junger, Wolfgang G.
dc.contributor.author Hirasawa, Hiroyuki
dc.contributor.author Hotchkiss, Richard S.
dc.contributor.author Li, Xiang-An
dc.contributor.author Radermacher, Peter
dc.contributor.author Redl, Heinz
dc.contributor.author Salomao, Reinaldo [UNIFESP]
dc.contributor.author Soebandrio, Amin
dc.contributor.author Thiemermann, Christoph
dc.contributor.author Vincent, Jean-Louis
dc.contributor.author Ward, Peter
dc.contributor.author Yao, Yong-Ming
dc.contributor.author Yu, Huang-Ping
dc.contributor.author Zingarelli, Basilia
dc.contributor.author Chaudry, Irshad H.
dc.date.accessioned 2016-01-24T14:37:19Z
dc.date.available 2016-01-24T14:37:19Z
dc.date.issued 2014-06-01
dc.identifier http://dx.doi.org/10.1097/SHK.0000000000000153
dc.identifier.citation Shock. Philadelphia: Lippincott Williams & Wilkins, v. 41, n. 6, p. 463-475, 2014.
dc.identifier.issn 1073-2322
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37793
dc.description.abstract Many preclinical studies in critical care medicine and related disciplines rely on hypothesis-driven research in mice. the underlying premise posits that mice sufficiently emulate numerous pathophysiologic alterations produced by trauma/sepsis and can serve as an experimental platform for answering clinically relevant questions. Recently, the lay press severely criticized the translational relevance of mouse models in critical care medicine. A series of provocative editorials were elicited by a highly publicized research report in the Proceedings of the National Academy of Sciences (PNAS; February 2013), which identified an unrecognized gene expression profile mismatch between human and murine leukocytes following burn/trauma/endotoxemia. Based on their data, the authors concluded that mouse models of trauma/inflammation are unsuitable for studying corresponding human conditions. We believe this conclusion was not justified. in conjunction with resulting negative commentary in the popular press, it can seriously jeopardize future basic research in critical care medicine. We will address some limitations of that PNAS report to provide a framework for discussing its conclusions and attempt to present a balanced summary of strengths/weaknesses of use of mouse models. While many investigators agree that animal research is a central component for improved patient outcomes, it is important to acknowledge known limitations in clinical translation from mouse to man. the scientific community is responsible to discuss valid limitations without overinterpretation. Hopefully, a balanced view of the strengths/weaknesses of using animals for trauma/endotoxemia/critical care research will not result in hasty discount of the clear need for using animals to advance treatment of critically ill patients. en
dc.format.extent 463-475
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Shock
dc.rights Acesso aberto
dc.subject Mouse models of critical illness en
dc.subject trauma en
dc.subject endotoxemia en
dc.subject sepsis en
dc.subject burn en
dc.title ABANDON the MOUSE RESEARCH SHIP? NOT JUST YET! en
dc.type Artigo
dc.contributor.institution AUVA Res Ctr
dc.contributor.institution Boston Univ
dc.contributor.institution Brigham & Womens Hosp
dc.contributor.institution Harvard Univ
dc.contributor.institution Penn State Coll Med
dc.contributor.institution Oslo Univ Hosp
dc.contributor.institution Ehime Univ
dc.contributor.institution Hosp Sirio Libanes
dc.contributor.institution Univ Szeged
dc.contributor.institution SUNY Upstate Med Univ
dc.contributor.institution Univ Messina
dc.contributor.institution Southern Med Univ Guangzhou
dc.contributor.institution Beth Israel Deaconess Med Ctr
dc.contributor.institution Chiba Univ
dc.contributor.institution Washington Univ
dc.contributor.institution Univ Kentucky
dc.contributor.institution Ulm Med Univ Clin
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Indonesia
dc.contributor.institution Queen Mary Univ London
dc.contributor.institution Univ Brussels
dc.contributor.institution Univ Michigan
dc.contributor.institution Chinese Peoples Liberat Army Gen Hosp
dc.contributor.institution Chang Gung Mem Hosp
dc.contributor.institution Cincinnati Childrens Hosp Med Ctr
dc.contributor.institution Univ Alabama Birmingham
dc.description.affiliation AUVA Res Ctr, Ludwig Boltzmann Inst Expt & Clin Traumatol, Vienna, Austria
dc.description.affiliation Boston Univ, Sch Med, Boston, MA 02118 USA
dc.description.affiliation Brigham & Womens Hosp, Boston, MA 02115 USA
dc.description.affiliation Harvard Univ, Sch Med, Boston, MA USA
dc.description.affiliation Penn State Coll Med, Hershey, PA USA
dc.description.affiliation Oslo Univ Hosp, Oslo, Norway
dc.description.affiliation Ehime Univ, Matsuyama, Ehime, Japan
dc.description.affiliation Hosp Sirio Libanes, Res & Educ Inst, São Paulo, Brazil
dc.description.affiliation Univ Szeged, Inst Surg Res, Szeged, Hungary
dc.description.affiliation SUNY Upstate Med Univ, Syracuse, NY 13210 USA
dc.description.affiliation Univ Messina, Dept Biol & Environm Sci, Messina, Italy
dc.description.affiliation Southern Med Univ Guangzhou, Guangzhou, Guangdong, Peoples R China
dc.description.affiliation Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
dc.description.affiliation Chiba Univ, Grad Sch Med, Chiba, Japan
dc.description.affiliation Washington Univ, Sch Med, St Louis, MO USA
dc.description.affiliation Univ Kentucky, Coll Med, Lexington, KY USA
dc.description.affiliation Ulm Med Univ Clin, Ulm, Germany
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Hosp São Paulo, Div Infect Dis,Dept Med, São Paulo, Brazil
dc.description.affiliation Univ Indonesia, Jakarta, Indonesia
dc.description.affiliation Queen Mary Univ London, William Harvey Res Inst, London, England
dc.description.affiliation Univ Brussels, Erasme Univ Hosp, Brussels, Belgium
dc.description.affiliation Univ Michigan, Sch Med, Ann Arbor, MI USA
dc.description.affiliation Chinese Peoples Liberat Army Gen Hosp, Hosp 1, Burns Inst, Beijing, Peoples R China
dc.description.affiliation Chang Gung Mem Hosp, Taipei 10591, Taiwan
dc.description.affiliation Cincinnati Childrens Hosp Med Ctr, Div Crit Care Med, Cincinnati, OH 45229 USA
dc.description.affiliation Univ Alabama Birmingham, Birmingham, AL 35294 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Hosp São Paulo, Div Infect Dis,Dept Med, São Paulo, Brazil
dc.identifier.doi 10.1097/SHK.0000000000000153
dc.description.source Web of Science
dc.identifier.wos WOS:000336217900002



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