Cox-2, EGFR, and ERBB-2 Expression in Cervical Intraepithelial Neoplasia and Cervical Cancer Using an Automated Imaging System

Cox-2, EGFR, and ERBB-2 Expression in Cervical Intraepithelial Neoplasia and Cervical Cancer Using an Automated Imaging System

Author Fukazawa, Elza M. Google Scholar
Baiocchi, Glauco Google Scholar
Soares, Fernando A. Google Scholar
Kumagai, Lillian Y. Google Scholar
Faloppa, Carlos C. Google Scholar
Badiglian-Filho, Levon Google Scholar
Coelho, Francisco R. G. Google Scholar
Goncalves, Wagner Jose Autor UNIFESP Google Scholar
Costa, Ronaldo L. R. Google Scholar
Goes, Joao C. S. Google Scholar
Institution AC Camargo Canc Hosp
Brazilian Inst Canc Control
Universidade Federal de São Paulo (UNIFESP)
Abstract We hypothesized that the activation of cyclooxygenase (COX)-2, epidermal growth factor receptor (EGFR), and ErbB-2 signaling is required for cervical intraepithelial neoplasia (CIN) lesions to progress to cervical cancer. A retrospective analysis was performed in 179 patients with Stage I squamous cell carcinoma (SCC) and 233 patients with CIN (112 CIN I, 47 CIN II, and 74 CIN III). COX-2, EGFR, and ErbB-2 expression was analyzed by immunohistochemistry using the ACIS III automated imaging system. the mean expression of COX-2, EGFR, and ErbB-2 was compared between the various stages of CIN and SCC. COX-2 mean expression was predominantly cytoplasmic, increasing significantly from CIN I to CIN II, CIN III, and SCC (P < 0.001). EGFR mean expression also rose significantly during tumor progression from CIN I to SCC (P=0.001). CIN I samples were negative for ErbB-2 expression. CIN II, CIN III, and SCC were considered positive for ErbB-2 expression in 2.2%, 14%, and 16.2% of cases, respectively. There was also a statistically significant correlation between increase of ErbB-2 positivity from CIN to SCC. We conclude that COX-2, EGFR, and ErbB-2 expression increase significantly during the progression of CIN to cancer.
Keywords Cyclooxygenase 2
ERBB-2
EGFR
Uterine cervical neoplasm
Cervical intraepithelial neoplasia
Language English
Date 2014-05-01
Published in International Journal of Gynecological Pathology. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 3, p. 225-234, 2014.
ISSN 0277-1691 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 225-234
Origin http://dx.doi.org/10.1097/PGP.0b013e318290405a
Access rights Closed access
Type Article
Web of Science ID WOS:000334474200003
URI http://repositorio.unifesp.br/handle/11600/37746

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